IgD attenuates the IgM-induced anergy response in transitional and mature B cells

IgD attenuates the IgM-induced anergy response in transitional and mature B cells

Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of anergic B cells that might go on to reactivate to f...

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Main Authors: Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg, Mehmet Yabas, Hannes Bergmann, Keisuke Horikawa, Carla Roots, Samantha Lambe, Clara Young, T. Dan Andrews, Matthew Field, Anselm Enders, Joanne H. Reed, Christopher C. Goodnow
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/33bf5d14b2104b7e9e5694830f9f9ee0
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https://doaj.org/article/33bf5d14b2104b7e9e5694830f9f9ee0

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