IgD attenuates the IgM-induced anergy response in transitional and mature B cells

Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of anergic B cells that might go on to reactivate to f...

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Autores principales:	Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg, Mehmet Yabas, Hannes Bergmann, Keisuke Horikawa, Carla Roots, Samantha Lambe, Clara Young, T. Dan Andrews, Matthew Field, Anselm Enders, Joanne H. Reed, Christopher C. Goodnow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33bf5d14b2104b7e9e5694830f9f9ee0
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spelling	oai:doaj.org-article:33bf5d14b2104b7e9e5694830f9f9ee02021-12-02T15:34:52ZIgD attenuates the IgM-induced anergy response in transitional and mature B cells10.1038/ncomms133812041-1723https://doaj.org/article/33bf5d14b2104b7e9e5694830f9f9ee02016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13381https://doaj.org/toc/2041-1723Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of anergic B cells that might go on to reactivate to foreign antigens and mutate away from self-reactivity.Zahra SabouriSamuel PerottiEmily SpieringsPeter HumburgMehmet YabasHannes BergmannKeisuke HorikawaCarla RootsSamantha LambeClara YoungT. Dan AndrewsMatthew FieldAnselm EndersJoanne H. ReedChristopher C. GoodnowNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zahra Sabouri Samuel Perotti Emily Spierings Peter Humburg Mehmet Yabas Hannes Bergmann Keisuke Horikawa Carla Roots Samantha Lambe Clara Young T. Dan Andrews Matthew Field Anselm Enders Joanne H. Reed Christopher C. Goodnow IgD attenuates the IgM-induced anergy response in transitional and mature B cells
description	Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of anergic B cells that might go on to reactivate to foreign antigens and mutate away from self-reactivity.
format	article
author	Zahra Sabouri Samuel Perotti Emily Spierings Peter Humburg Mehmet Yabas Hannes Bergmann Keisuke Horikawa Carla Roots Samantha Lambe Clara Young T. Dan Andrews Matthew Field Anselm Enders Joanne H. Reed Christopher C. Goodnow
author_facet	Zahra Sabouri Samuel Perotti Emily Spierings Peter Humburg Mehmet Yabas Hannes Bergmann Keisuke Horikawa Carla Roots Samantha Lambe Clara Young T. Dan Andrews Matthew Field Anselm Enders Joanne H. Reed Christopher C. Goodnow
author_sort	Zahra Sabouri
title	IgD attenuates the IgM-induced anergy response in transitional and mature B cells
title_short	IgD attenuates the IgM-induced anergy response in transitional and mature B cells
title_full	IgD attenuates the IgM-induced anergy response in transitional and mature B cells
title_fullStr	IgD attenuates the IgM-induced anergy response in transitional and mature B cells
title_full_unstemmed	IgD attenuates the IgM-induced anergy response in transitional and mature B cells
title_sort	igd attenuates the igm-induced anergy response in transitional and mature b cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/33bf5d14b2104b7e9e5694830f9f9ee0
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IgD attenuates the IgM-induced anergy response in transitional and mature B cells

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