Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs

PARP1 is the target of clinically approved anti-cancer drugs whose in vivo efficacy has been hard to predict. Here the authors show how an altered active site formed between PARP1 and Histone PARylation Factor 1 (HPF1) changes the efficacy of some of these inhibitors.

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Autores principales: Johannes Rudolph, Genevieve Roberts, Karolin Luger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/33d6d10fa6924050954dfbd2aa320cee
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