Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

Abemaciclib is a third generation CDK-directed drug used in the treatment of HR + /HER2 negative advanced or metastatic breast cancer. Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A are also targeted by Abemaciclib.

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Autores principales:	Ines H. Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Düster, Jinhua Wang, Nathanael S. Gray, Matthias Geyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33e83e6764fc43a883e68121456aa437
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spelling	oai:doaj.org-article:33e83e6764fc43a883e68121456aa4372021-11-21T12:35:20ZAbemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation10.1038/s41467-021-26935-z2041-1723https://doaj.org/article/33e83e6764fc43a883e68121456aa4372021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26935-zhttps://doaj.org/toc/2041-1723Abemaciclib is a third generation CDK-directed drug used in the treatment of HR + /HER2 negative advanced or metastatic breast cancer. Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A are also targeted by Abemaciclib.Ines H. KaltheunerKanchan AnandJonas MoeckingRobert DüsterJinhua WangNathanael S. GrayMatthias GeyerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ines H. Kaltheuner Kanchan Anand Jonas Moecking Robert Düster Jinhua Wang Nathanael S. Gray Matthias Geyer Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
description	Abemaciclib is a third generation CDK-directed drug used in the treatment of HR + /HER2 negative advanced or metastatic breast cancer. Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A are also targeted by Abemaciclib.
format	article
author	Ines H. Kaltheuner Kanchan Anand Jonas Moecking Robert Düster Jinhua Wang Nathanael S. Gray Matthias Geyer
author_facet	Ines H. Kaltheuner Kanchan Anand Jonas Moecking Robert Düster Jinhua Wang Nathanael S. Gray Matthias Geyer
author_sort	Ines H. Kaltheuner
title	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
title_short	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
title_full	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
title_fullStr	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
title_full_unstemmed	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
title_sort	abemaciclib is a potent inhibitor of dyrk1a and hip kinases involved in transcriptional regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33e83e6764fc43a883e68121456aa437
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Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

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