The Combination of Rifampin plus Moxifloxacin Is Synergistic for Suppression of Resistance but Antagonistic for Cell Kill of <italic toggle="yes">Mycobacterium tuberculosis</italic> as Determined in a Hollow-Fiber Infection Model

The Combination of Rifampin plus Moxifloxacin Is Synergistic for Suppression of Resistance but Antagonistic for Cell Kill of <italic toggle="yes">Mycobacterium tuberculosis</italic> as Determined in a Hollow-Fiber Infection Model

ABSTRACT Moxifloxacin is under development for expanded use against Mycobacterium tuberculosis. Rifampin is a mainstay of therapy. We examined the interaction of moxifloxacin plus rifampin for log-phase and nonreplicating persister (NRP) organisms. For this evaluation, we employed our hollow-fiber i...

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Autores principales: G. L. Drusano, Nicole Sgambati, Adam Eichas, David L. Brown, Robert Kulawy, Arnold Louie
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2010
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/346a155c92eb441da601c67a03e408da
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