Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications

<i>Polygoni cuspidati</i> root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve t...

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Autores principales:	Magdalena Paczkowska-Walendowska, Emilia Szymańska, Katarzyna Winnicka, Dominik Szwajgier, Ewa Baranowska-Wójcik, Marek A. Ruchała, Marek Simon, Judyta Cielecka-Piontek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Polygoni cuspidati</i> extract mucoadhesiveness tablet cyclodextrin resveratrol dental application Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3473086bab974c6499ee7dde94a8029e
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spelling	oai:doaj.org-article:3473086bab974c6499ee7dde94a8029e2021-11-25T18:41:47ZCyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications10.3390/pharmaceutics131119161999-4923https://doaj.org/article/3473086bab974c6499ee7dde94a8029e2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1916https://doaj.org/toc/1999-4923<i>Polygoni cuspidati</i> root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of resveratrol and to assure its high content in plant material, an ultrasound-assisted extraction method was applied. The addition of cyclodextrin was found to increase the extraction efficiency of resveratrol (from 13 to 297 µg per 1 g of plant material in case of 50% ethanol extracts) and enhanced its antioxidant activity as compared to pure <i>Polygoni cuspidati</i> extract/resveratrol. Cyclodextrin plays the role of a functional extract regarding technological properties (increasing the extraction of resveratrol from the extract, improving mucoadhesive properties). Therefore, the aim of this study was to develop mucoadhesive tablets containing combinations of the <i>Polygoni cuspidati</i> extract with a cyclodextrin carrier for buccal delivery. The tests sequentially included extract preparation and characterization of its physical and biological properties and then formulation studies with a broad description of the prototype properties. The test results indicate that cyclodextrin increases the efficiency of resveratrol extraction from <i>Polygoni cuspidati</i> rhizome, which is a rich source of resveratrol, and its extract enclosed in a mucoadhesive tablet guarantees prolonged action at the site of administration.Magdalena Paczkowska-WalendowskaEmilia SzymańskaKatarzyna WinnickaDominik SzwajgierEwa Baranowska-WójcikMarek A. RuchałaMarek SimonJudyta Cielecka-PiontekMDPI AGarticle<i>Polygoni cuspidati</i> extractmucoadhesivenesstabletcyclodextrinresveratroldental applicationPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1916, p 1916 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Polygoni cuspidati</i> extract mucoadhesiveness tablet cyclodextrin resveratrol dental application Pharmacy and materia medica RS1-441
spellingShingle	<i>Polygoni cuspidati</i> extract mucoadhesiveness tablet cyclodextrin resveratrol dental application Pharmacy and materia medica RS1-441 Magdalena Paczkowska-Walendowska Emilia Szymańska Katarzyna Winnicka Dominik Szwajgier Ewa Baranowska-Wójcik Marek A. Ruchała Marek Simon Judyta Cielecka-Piontek Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications
description	<i>Polygoni cuspidati</i> root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of resveratrol and to assure its high content in plant material, an ultrasound-assisted extraction method was applied. The addition of cyclodextrin was found to increase the extraction efficiency of resveratrol (from 13 to 297 µg per 1 g of plant material in case of 50% ethanol extracts) and enhanced its antioxidant activity as compared to pure <i>Polygoni cuspidati</i> extract/resveratrol. Cyclodextrin plays the role of a functional extract regarding technological properties (increasing the extraction of resveratrol from the extract, improving mucoadhesive properties). Therefore, the aim of this study was to develop mucoadhesive tablets containing combinations of the <i>Polygoni cuspidati</i> extract with a cyclodextrin carrier for buccal delivery. The tests sequentially included extract preparation and characterization of its physical and biological properties and then formulation studies with a broad description of the prototype properties. The test results indicate that cyclodextrin increases the efficiency of resveratrol extraction from <i>Polygoni cuspidati</i> rhizome, which is a rich source of resveratrol, and its extract enclosed in a mucoadhesive tablet guarantees prolonged action at the site of administration.
format	article
author	Magdalena Paczkowska-Walendowska Emilia Szymańska Katarzyna Winnicka Dominik Szwajgier Ewa Baranowska-Wójcik Marek A. Ruchała Marek Simon Judyta Cielecka-Piontek
author_facet	Magdalena Paczkowska-Walendowska Emilia Szymańska Katarzyna Winnicka Dominik Szwajgier Ewa Baranowska-Wójcik Marek A. Ruchała Marek Simon Judyta Cielecka-Piontek
author_sort	Magdalena Paczkowska-Walendowska
title	Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications
title_short	Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications
title_full	Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications
title_fullStr	Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications
title_full_unstemmed	Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications
title_sort	cyclodextrin as functional carrier in development of mucoadhesive tablets containing <i>polygoni cuspidati</i> extract with potential for dental applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3473086bab974c6499ee7dde94a8029e
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Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing <i>Polygoni cuspidati</i> Extract with Potential for Dental Applications

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