Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Abstract The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing antibody (NAb) responses in rabbits. The...

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Détails bibliographiques
Auteurs principaux: Kwinten Sliepen, Edith Schermer, Ilja Bontjer, Judith A. Burger, Réka Felfödiné Lévai, Philipp Mundsperger, Philip J. M. Brouwer, Monica Tolazzi, Atilla Farsang, Dietmar Katinger, John P. Moore, Gabriella Scarlatti, Robin J. Shattock, Quentin J. Sattentau, Rogier W. Sanders
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/3493c21b5fee4dc2a902a4cfd21185c1
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https://doaj.org/article/3493c21b5fee4dc2a902a4cfd21185c1

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