Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

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Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Abstract The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing antibody (NAb) responses in rabbits. The...

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Auteurs principaux:	Kwinten Sliepen, Edith Schermer, Ilja Bontjer, Judith A. Burger, Réka Felfödiné Lévai, Philipp Mundsperger, Philip J. M. Brouwer, Monica Tolazzi, Atilla Farsang, Dietmar Katinger, John P. Moore, Gabriella Scarlatti, Robin J. Shattock, Quentin J. Sattentau, Rogier W. Sanders
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Accès en ligne:	https://doaj.org/article/3493c21b5fee4dc2a902a4cfd21185c1
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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