Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.

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Autores principales:	Alexander Teumer, Layal Chaker, Stefan Groeneweg, Yong Li, Celia Di Munno, Caterina Barbieri, Ulla T. Schultheiss, Michela Traglia, Tarunveer S. Ahluwalia, Masato Akiyama, Emil Vincent R. Appel, Dan E. Arking, Alice Arnold, Arne Astrup, Marian Beekman, John P. Beilby, Sofie Bekaert, Eric Boerwinkle, Suzanne J. Brown, Marc De Buyzere, Purdey J. Campbell, Graziano Ceresini, Charlotte Cerqueira, Francesco Cucca, Ian J. Deary, Joris Deelen, Kai-Uwe Eckardt, Arif B. Ekici, Johan G. Eriksson, Luigi Ferrrucci, Tom Fiers, Edoardo Fiorillo, Ian Ford, Caroline S. Fox, Christian Fuchsberger, Tessel E. Galesloot, Christian Gieger, Martin Gögele, Alessandro De Grandi, Niels Grarup, Karin Halina Greiser, Kadri Haljas, Torben Hansen, Sarah E. Harris, Diana van Heemst, Martin den Heijer, Andrew A. Hicks, Wouter den Hollander, Georg Homuth, Jennie Hui, M. Arfan Ikram, Till Ittermann, Richard A. Jensen, Jiaojiao Jing, J. Wouter Jukema, Eero Kajantie, Yoichiro Kamatani, Elisa Kasbohm, Jean-Marc Kaufman, Lambertus A. Kiemeney, Margreet Kloppenburg, Florian Kronenberg, Michiaki Kubo, Jari Lahti, Bruno Lapauw, Shuo Li, David C. M. Liewald, Lifelines Cohort Study, Ee Mun Lim, Allan Linneberg, Michela Marina, Deborah Mascalzoni, Koichi Matsuda, Daniel Medenwald, Christa Meisinger, Ingrid Meulenbelt, Tim De Meyer, Henriette E. Meyer zu Schwabedissen, Rafael Mikolajczyk, Matthijs Moed, Romana T. Netea-Maier, Ilja M. Nolte, Yukinori Okada, Mauro Pala, Cristian Pattaro, Oluf Pedersen, Astrid Petersmann, Eleonora Porcu, Iris Postmus, Peter P. Pramstaller, Bruce M. Psaty, Yolande F. M. Ramos, Rajesh Rawal, Paul Redmond, J. Brent Richards, Ernst R. Rietzschel, Fernando Rivadeneira, Greet Roef, Jerome I. Rotter, Cinzia F. Sala, David Schlessinger, Elizabeth Selvin, P. Eline Slagboom, Nicole Soranzo, Thorkild I. A. Sørensen, Timothy D. Spector, John M. Starr, David J. Stott, Youri Taes, Daniel Taliun, Toshiko Tanaka, Betina Thuesen, Daniel Tiller, Daniela Toniolo, Andre G. Uitterlinden, W. Edward Visser, John P. Walsh, Scott G. Wilson, Bruce H. R. Wolffenbuttel, Qiong Yang, Hou-Feng Zheng, Anne Cappola, Robin P. Peeters, Silvia Naitza, Henry Völzke, Serena Sanna, Anna Köttgen, Theo J. Visser, Marco Medici
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34ab5dc1d5c54e85877b61677f6ec6a8
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spelling	oai:doaj.org-article:34ab5dc1d5c54e85877b61677f6ec6a82021-12-02T15:34:22ZGenome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation10.1038/s41467-018-06356-12041-1723https://doaj.org/article/34ab5dc1d5c54e85877b61677f6ec6a82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06356-1https://doaj.org/toc/2041-1723Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.Alexander TeumerLayal ChakerStefan GroenewegYong LiCelia Di MunnoCaterina BarbieriUlla T. SchultheissMichela TragliaTarunveer S. AhluwaliaMasato AkiyamaEmil Vincent R. AppelDan E. ArkingAlice ArnoldArne AstrupMarian BeekmanJohn P. BeilbySofie BekaertEric BoerwinkleSuzanne J. BrownMarc De BuyzerePurdey J. CampbellGraziano CeresiniCharlotte CerqueiraFrancesco CuccaIan J. DearyJoris DeelenKai-Uwe EckardtArif B. EkiciJohan G. ErikssonLuigi FerrrucciTom FiersEdoardo FiorilloIan FordCaroline S. FoxChristian FuchsbergerTessel E. GaleslootChristian GiegerMartin GögeleAlessandro De GrandiNiels GrarupKarin Halina GreiserKadri HaljasTorben HansenSarah E. HarrisDiana van HeemstMartin den HeijerAndrew A. HicksWouter den HollanderGeorg HomuthJennie HuiM. Arfan IkramTill IttermannRichard A. JensenJiaojiao JingJ. Wouter JukemaEero KajantieYoichiro KamataniElisa KasbohmJean-Marc KaufmanLambertus A. KiemeneyMargreet KloppenburgFlorian KronenbergMichiaki KuboJari LahtiBruno LapauwShuo LiDavid C. M. LiewaldLifelines Cohort StudyEe Mun LimAllan LinnebergMichela MarinaDeborah MascalzoniKoichi MatsudaDaniel MedenwaldChrista MeisingerIngrid MeulenbeltTim De MeyerHenriette E. Meyer zu SchwabedissenRafael MikolajczykMatthijs MoedRomana T. Netea-MaierIlja M. NolteYukinori OkadaMauro PalaCristian PattaroOluf PedersenAstrid PetersmannEleonora PorcuIris PostmusPeter P. PramstallerBruce M. PsatyYolande F. M. RamosRajesh RawalPaul RedmondJ. Brent RichardsErnst R. RietzschelFernando RivadeneiraGreet RoefJerome I. RotterCinzia F. SalaDavid SchlessingerElizabeth SelvinP. Eline SlagboomNicole SoranzoThorkild I. A. SørensenTimothy D. SpectorJohn M. StarrDavid J. StottYouri TaesDaniel TaliunToshiko TanakaBetina ThuesenDaniel TillerDaniela TonioloAndre G. UitterlindenW. Edward VisserJohn P. WalshScott G. WilsonBruce H. R. WolffenbuttelQiong YangHou-Feng ZhengAnne CappolaRobin P. PeetersSilvia NaitzaHenry VölzkeSerena SannaAnna KöttgenTheo J. VisserMarco MediciNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander Teumer Layal Chaker Stefan Groeneweg Yong Li Celia Di Munno Caterina Barbieri Ulla T. Schultheiss Michela Traglia Tarunveer S. Ahluwalia Masato Akiyama Emil Vincent R. Appel Dan E. Arking Alice Arnold Arne Astrup Marian Beekman John P. Beilby Sofie Bekaert Eric Boerwinkle Suzanne J. Brown Marc De Buyzere Purdey J. Campbell Graziano Ceresini Charlotte Cerqueira Francesco Cucca Ian J. Deary Joris Deelen Kai-Uwe Eckardt Arif B. Ekici Johan G. Eriksson Luigi Ferrrucci Tom Fiers Edoardo Fiorillo Ian Ford Caroline S. Fox Christian Fuchsberger Tessel E. Galesloot Christian Gieger Martin Gögele Alessandro De Grandi Niels Grarup Karin Halina Greiser Kadri Haljas Torben Hansen Sarah E. Harris Diana van Heemst Martin den Heijer Andrew A. Hicks Wouter den Hollander Georg Homuth Jennie Hui M. Arfan Ikram Till Ittermann Richard A. Jensen Jiaojiao Jing J. Wouter Jukema Eero Kajantie Yoichiro Kamatani Elisa Kasbohm Jean-Marc Kaufman Lambertus A. Kiemeney Margreet Kloppenburg Florian Kronenberg Michiaki Kubo Jari Lahti Bruno Lapauw Shuo Li David C. M. Liewald Lifelines Cohort Study Ee Mun Lim Allan Linneberg Michela Marina Deborah Mascalzoni Koichi Matsuda Daniel Medenwald Christa Meisinger Ingrid Meulenbelt Tim De Meyer Henriette E. Meyer zu Schwabedissen Rafael Mikolajczyk Matthijs Moed Romana T. Netea-Maier Ilja M. Nolte Yukinori Okada Mauro Pala Cristian Pattaro Oluf Pedersen Astrid Petersmann Eleonora Porcu Iris Postmus Peter P. Pramstaller Bruce M. Psaty Yolande F. M. Ramos Rajesh Rawal Paul Redmond J. Brent Richards Ernst R. Rietzschel Fernando Rivadeneira Greet Roef Jerome I. Rotter Cinzia F. Sala David Schlessinger Elizabeth Selvin P. Eline Slagboom Nicole Soranzo Thorkild I. A. Sørensen Timothy D. Spector John M. Starr David J. Stott Youri Taes Daniel Taliun Toshiko Tanaka Betina Thuesen Daniel Tiller Daniela Toniolo Andre G. Uitterlinden W. Edward Visser John P. Walsh Scott G. Wilson Bruce H. R. Wolffenbuttel Qiong Yang Hou-Feng Zheng Anne Cappola Robin P. Peeters Silvia Naitza Henry Völzke Serena Sanna Anna Köttgen Theo J. Visser Marco Medici Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
description	Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.
format	article
author	Alexander Teumer Layal Chaker Stefan Groeneweg Yong Li Celia Di Munno Caterina Barbieri Ulla T. Schultheiss Michela Traglia Tarunveer S. Ahluwalia Masato Akiyama Emil Vincent R. Appel Dan E. Arking Alice Arnold Arne Astrup Marian Beekman John P. Beilby Sofie Bekaert Eric Boerwinkle Suzanne J. Brown Marc De Buyzere Purdey J. Campbell Graziano Ceresini Charlotte Cerqueira Francesco Cucca Ian J. Deary Joris Deelen Kai-Uwe Eckardt Arif B. Ekici Johan G. Eriksson Luigi Ferrrucci Tom Fiers Edoardo Fiorillo Ian Ford Caroline S. Fox Christian Fuchsberger Tessel E. Galesloot Christian Gieger Martin Gögele Alessandro De Grandi Niels Grarup Karin Halina Greiser Kadri Haljas Torben Hansen Sarah E. Harris Diana van Heemst Martin den Heijer Andrew A. Hicks Wouter den Hollander Georg Homuth Jennie Hui M. Arfan Ikram Till Ittermann Richard A. Jensen Jiaojiao Jing J. Wouter Jukema Eero Kajantie Yoichiro Kamatani Elisa Kasbohm Jean-Marc Kaufman Lambertus A. Kiemeney Margreet Kloppenburg Florian Kronenberg Michiaki Kubo Jari Lahti Bruno Lapauw Shuo Li David C. M. Liewald Lifelines Cohort Study Ee Mun Lim Allan Linneberg Michela Marina Deborah Mascalzoni Koichi Matsuda Daniel Medenwald Christa Meisinger Ingrid Meulenbelt Tim De Meyer Henriette E. Meyer zu Schwabedissen Rafael Mikolajczyk Matthijs Moed Romana T. Netea-Maier Ilja M. Nolte Yukinori Okada Mauro Pala Cristian Pattaro Oluf Pedersen Astrid Petersmann Eleonora Porcu Iris Postmus Peter P. Pramstaller Bruce M. Psaty Yolande F. M. Ramos Rajesh Rawal Paul Redmond J. Brent Richards Ernst R. Rietzschel Fernando Rivadeneira Greet Roef Jerome I. Rotter Cinzia F. Sala David Schlessinger Elizabeth Selvin P. Eline Slagboom Nicole Soranzo Thorkild I. A. Sørensen Timothy D. Spector John M. Starr David J. Stott Youri Taes Daniel Taliun Toshiko Tanaka Betina Thuesen Daniel Tiller Daniela Toniolo Andre G. Uitterlinden W. Edward Visser John P. Walsh Scott G. Wilson Bruce H. R. Wolffenbuttel Qiong Yang Hou-Feng Zheng Anne Cappola Robin P. Peeters Silvia Naitza Henry Völzke Serena Sanna Anna Köttgen Theo J. Visser Marco Medici
author_facet	Alexander Teumer Layal Chaker Stefan Groeneweg Yong Li Celia Di Munno Caterina Barbieri Ulla T. Schultheiss Michela Traglia Tarunveer S. Ahluwalia Masato Akiyama Emil Vincent R. Appel Dan E. Arking Alice Arnold Arne Astrup Marian Beekman John P. Beilby Sofie Bekaert Eric Boerwinkle Suzanne J. Brown Marc De Buyzere Purdey J. Campbell Graziano Ceresini Charlotte Cerqueira Francesco Cucca Ian J. Deary Joris Deelen Kai-Uwe Eckardt Arif B. Ekici Johan G. Eriksson Luigi Ferrrucci Tom Fiers Edoardo Fiorillo Ian Ford Caroline S. Fox Christian Fuchsberger Tessel E. Galesloot Christian Gieger Martin Gögele Alessandro De Grandi Niels Grarup Karin Halina Greiser Kadri Haljas Torben Hansen Sarah E. Harris Diana van Heemst Martin den Heijer Andrew A. Hicks Wouter den Hollander Georg Homuth Jennie Hui M. Arfan Ikram Till Ittermann Richard A. Jensen Jiaojiao Jing J. Wouter Jukema Eero Kajantie Yoichiro Kamatani Elisa Kasbohm Jean-Marc Kaufman Lambertus A. Kiemeney Margreet Kloppenburg Florian Kronenberg Michiaki Kubo Jari Lahti Bruno Lapauw Shuo Li David C. M. Liewald Lifelines Cohort Study Ee Mun Lim Allan Linneberg Michela Marina Deborah Mascalzoni Koichi Matsuda Daniel Medenwald Christa Meisinger Ingrid Meulenbelt Tim De Meyer Henriette E. Meyer zu Schwabedissen Rafael Mikolajczyk Matthijs Moed Romana T. Netea-Maier Ilja M. Nolte Yukinori Okada Mauro Pala Cristian Pattaro Oluf Pedersen Astrid Petersmann Eleonora Porcu Iris Postmus Peter P. Pramstaller Bruce M. Psaty Yolande F. M. Ramos Rajesh Rawal Paul Redmond J. Brent Richards Ernst R. Rietzschel Fernando Rivadeneira Greet Roef Jerome I. Rotter Cinzia F. Sala David Schlessinger Elizabeth Selvin P. Eline Slagboom Nicole Soranzo Thorkild I. A. Sørensen Timothy D. Spector John M. Starr David J. Stott Youri Taes Daniel Taliun Toshiko Tanaka Betina Thuesen Daniel Tiller Daniela Toniolo Andre G. Uitterlinden W. Edward Visser John P. Walsh Scott G. Wilson Bruce H. R. Wolffenbuttel Qiong Yang Hou-Feng Zheng Anne Cappola Robin P. Peeters Silvia Naitza Henry Völzke Serena Sanna Anna Köttgen Theo J. Visser Marco Medici
author_sort	Alexander Teumer
title	Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
title_short	Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
title_full	Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
title_fullStr	Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
title_full_unstemmed	Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
title_sort	genome-wide analyses identify a role for slc17a4 and aadat in thyroid hormone regulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/34ab5dc1d5c54e85877b61677f6ec6a8
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Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

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