Small nucleoli are a cellular hallmark of longevity

by Varnesh Tiku, Chirag Jain, Yotam Raz, Shuhei Nakamura, Bree Heestand, Wei Liu, Martin Späth, H. Eka. D. Suchiman, Roman-Ulrich Müller, P. Eline Slagboom, Linda Partridge, Adam Antebi
Published 2017

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study.

by Marjon Stijntjes, Anton J M de Craen, Diana van Heemst, Carel G M Meskers, Mark A van Buchem, Rudi G J Westendorp, P Eline Slagboom, Andrea B Maier
Published 2013

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

by Niels van den Berg, Mar Rodríguez-Girondo, Ingrid K. van Dijk, Rick J. Mourits, Kees Mandemakers, Angelique A. P. O. Janssens, Marian Beekman, Ken R. Smith, P. Eline Slagboom
Published 2019

Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.

by Jeffrey J W Verschuren, Stella Trompet, M Lourdes Sampietro, Bastiaan T Heijmans, Werner Koch, Adnan Kastrati, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Paul H A Quax, J Wouter Jukema
Published 2013

ApoE plasma levels and risk of cardiovascular mortality in old age.

by Simon P Mooijaart, Jimmy F P Berbée, Diana van Heemst, Louis M Havekes, Anton J M de Craen, P Eline Slagboom, Patrick C N Rensen, Rudi G J Westendorp
Published 2006

Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity.

by L Renee Ruhaak, Hae-Won Uh, Marian Beekman, Carolien A M Koeleman, Cornelis H Hokke, Rudi G J Westendorp, Manfred Wuhrer, Jeanine J Houwing-Duistermaat, P Eline Slagboom, André M Deelder
Published 2010

Homocysteine and familial longevity: the Leiden Longevity Study.

by Carolien A Wijsman, Diana van Heemst, Maarten P Rozing, P Eline Slagboom, Marian Beekman, Anton J M de Craen, Andrea B Maier, Rudi G J Westendorp, Henk J Blom, Simon P Mooijaart
Published 2011

Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A.

by L Renee Ruhaak, Carolien A M Koeleman, Hae-Won Uh, Jord C Stam, Diana van Heemst, Andrea B Maier, Jeanine J Houwing-Duistermaat, Paul J Hensbergen, P Eline Slagboom, André M Deelder, Manfred Wuhrer
Published 2013

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.

by Yolande F M Ramos, Wouter den Hollander, Judith V M G Bovée, Nils Bomer, Ruud van der Breggen, Nico Lakenberg, J Christiaan Keurentjes, Jelle J Goeman, P Eline Slagboom, Rob G H H Nelissen, Steffan D Bos, Ingrid Meulenbelt
Published 2014

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

by Raymond Noordam, Steffy W M Jansen, Abimbola A Akintola, Nicole Y L Oei, Andrea B Maier, Hanno Pijl, P Eline Slagboom, Rudi G J Westendorp, Jeroen van der Grond, Anton J M de Craen, Diana van Heemst, Leiden Longevity Study group
Published 2012

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study.

by Yingchang Lu, Anika Vaarhorst, Audrey H H Merry, Martijn E T Dollé, Robert Hovenier, Sandra Imholz, Leo J Schouten, Bastiaan T Heijmans, Michael Müller, P Eline Slagboom, Piet A van den Brandt, Anton P M Gorgels, Jolanda M A Boer, Edith J M Feskens
Published 2012

Genetic and environmental influences interact with age and sex in shaping the human methylome

by Jenny van Dongen, Michel G. Nivard, Gonneke Willemsen, Jouke-Jan Hottenga, Quinta Helmer, Conor V. Dolan, Erik A. Ehli, Gareth E. Davies, Maarten van Iterson, Charles E. Breeze, Stephan Beck, BIOS Consortium, H. Eka Suchiman, Rick Jansen, Joyce B. van Meurs, Bastiaan T. Heijmans, P. Eline Slagboom, Dorret I. Boomsma
Published 2016

Genome-wide identification of directed gene networks using large-scale population genomics data

by René Luijk, Koen F. Dekkers, Maarten van Iterson, Wibowo Arindrarto, Annique Claringbould, Paul Hop, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Lude Franke, Peter A. C. ’t Hoen, Rick Jansen, Joyce van Meurs, Hailiang Mei, P. Eline Slagboom, Bastiaan T. Heijmans, Erik W. van Zwet, BIOS (Biobank-based Integrative Omics Study) Consortium
Published 2018

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, Harmen H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

by René Luijk, Haoyu Wu, Cavin K Ward-Caviness, Eilis Hannon, Elena Carnero-Montoro, Josine L. Min, Pooja Mandaviya, Martina Müller-Nurasyid, Hailiang Mei, Silvere M. van der Maarel, BIOS Consortium, Caroline Relton, Jonathan Mill, Melanie Waldenberger, Jordana T. Bell, Rick Jansen, Alexandra Zhernakova, Lude Franke, Peter A. C. ‘t Hoen, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Joyce van Meurs, Lucia Daxinger, P. Eline Slagboom, Erik W. van Zwet, Bastiaan T. Heijmans
Published 2018

A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

by Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, Freerk van Dijk, Fereydoun Hormozdiari, The Genome of the Netherlands Consortium, André G. Uitterlinden, Cornelia M. van Duijn, Evan E. Eichler, Paul I. W. de Bakker, Morris A. Swertz, Cisca Wijmenga, Gert-Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Alexander Schönhuth, Kai Ye, Victor Guryev
Published 2016

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

by Joris Deelen, Johannes Kettunen, Krista Fischer, Ashley van der Spek, Stella Trompet, Gabi Kastenmüller, Andy Boyd, Jonas Zierer, Erik B. van den Akker, Mika Ala-Korpela, Najaf Amin, Ayse Demirkan, Mohsen Ghanbari, Diana van Heemst, M. Arfan Ikram, Jan Bert van Klinken, Simon P. Mooijaart, Annette Peters, Veikko Salomaa, Naveed Sattar, Tim D. Spector, Henning Tiemeier, Aswin Verhoeven, Melanie Waldenberger, Peter Würtz, George Davey Smith, Andres Metspalu, Markus Perola, Cristina Menni, Johanna M. Geleijnse, Fotios Drenos, Marian Beekman, J. Wouter Jukema, Cornelia M. van Duijn, P. Eline Slagboom
Published 2019

Identical twins carry a persistent epigenetic signature of early genome programming

by Jenny van Dongen, Scott D. Gordon, Allan F. McRae, Veronika V. Odintsova, Hamdi Mbarek, Charles E. Breeze, Karen Sugden, Sara Lundgren, Juan E. Castillo-Fernandez, Eilis Hannon, Terrie E. Moffitt, Fiona A. Hagenbeek, Catharina E. M. van Beijsterveldt, Jouke Jan Hottenga, Pei-Chien Tsai, BIOS Consortium, Genetics of DNA Methylation Consortium, Josine L. Min, Gibran Hemani, Erik A. Ehli, Franziska Paul, Claudio D. Stern, Bastiaan T. Heijmans, P. Eline Slagboom, Lucia Daxinger, Silvère M. van der Maarel, Eco J. C. de Geus, Gonneke Willemsen, Grant W. Montgomery, Bruno Reversade, Miina Ollikainen, Jaakko Kaprio, Tim D. Spector, Jordana T. Bell, Jonathan Mill, Avshalom Caspi, Nicholas G. Martin, Dorret I. Boomsma
Published 2021

Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling

by Nicolien A. van Vliet, Maxime M. Bos, Carisha S. Thesing, Layal Chaker, Maik Pietzner, Evelyn Houtman, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Rima Mustafa, Fariba Ahmadizar, Marian Beekman, Mariska Bot, Kathrin Budde, Constantinos Christodoulides, Abbas Dehghan, Christian Delles, Paul Elliott, Marina Evangelou, He Gao, Mohsen Ghanbari, Antonius E. van Herwaarden, M. Arfan Ikram, Martin Jaeger, J. Wouter Jukema, Ibrahim Karaman, Fredrik Karpe, Margreet Kloppenburg, Jennifer M. T. A. Meessen, Ingrid Meulenbelt, Yuri Milaneschi, Simon P. Mooijaart, Dennis O. Mook-Kanamori, Mihai G. Netea, Romana T. Netea-Maier, Robin P. Peeters, Brenda W. J. H. Penninx, Naveed Sattar, P. Eline Slagboom, H. Eka D. Suchiman, Henry Völzke, Ko Willems van Dijk, Raymond Noordam, Diana van Heemst, BBMRI Metabolomics Consortium
Published 2021