mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation

Autophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion.

Guardado en:
Detalles Bibliográficos
Autores principales: Hong Huang, Qinqin Ouyang, Min Zhu, Haijia Yu, Kunrong Mei, Rong Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/34d729342eb24e5ea2c8dc490fe613ff
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!