mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation

Autophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion.

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Autores principales:	Hong Huang, Qinqin Ouyang, Min Zhu, Haijia Yu, Kunrong Mei, Rong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34d729342eb24e5ea2c8dc490fe613ff
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spelling	oai:doaj.org-article:34d729342eb24e5ea2c8dc490fe613ff2021-11-21T12:38:51ZmTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation10.1038/s41467-021-26824-52041-1723https://doaj.org/article/34d729342eb24e5ea2c8dc490fe613ff2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26824-5https://doaj.org/toc/2041-1723Autophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion.Hong HuangQinqin OuyangMin ZhuHaijia YuKunrong MeiRong LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong Huang Qinqin Ouyang Min Zhu Haijia Yu Kunrong Mei Rong Liu mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
description	Autophagy relies on coordinated fusion of organelle membranes, although the interplay between the regulatory machinery is not well studied. Here, the authors show that SNARE complex formation is inhibited by mTORC1 phosphorylation of VAMP8, which prevents autophagosome-lysosome fusion.
format	article
author	Hong Huang Qinqin Ouyang Min Zhu Haijia Yu Kunrong Mei Rong Liu
author_facet	Hong Huang Qinqin Ouyang Min Zhu Haijia Yu Kunrong Mei Rong Liu
author_sort	Hong Huang
title	mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
title_short	mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
title_full	mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
title_fullStr	mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
title_full_unstemmed	mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
title_sort	mtor-mediated phosphorylation of vamp8 and scfd1 regulates autophagosome maturation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34d729342eb24e5ea2c8dc490fe613ff
work_keys_str_mv	AT honghuang mtormediatedphosphorylationofvamp8andscfd1regulatesautophagosomematuration AT qinqinouyang mtormediatedphosphorylationofvamp8andscfd1regulatesautophagosomematuration AT minzhu mtormediatedphosphorylationofvamp8andscfd1regulatesautophagosomematuration AT haijiayu mtormediatedphosphorylationofvamp8andscfd1regulatesautophagosomematuration AT kunrongmei mtormediatedphosphorylationofvamp8andscfd1regulatesautophagosomematuration AT rongliu mtormediatedphosphorylationofvamp8andscfd1regulatesautophagosomematuration
_version_	1718418876121743360

mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation

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