Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase

Human manganese superoxide dismutase (MnSOD) is an oxidoreductase that uses concerted proton and electron transfers to reduce the levels of superoxide radicals in mitochondria, but mechanistic insights into this process are limited. Here, the authors report neutron crystal structures of Mn3+SOD and...

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Autores principales:	Jahaun Azadmanesh, William E. Lutz, Leighton Coates, Kevin L. Weiss, Gloria E. O. Borgstahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34eb2c72ba2b44c2b7fd4909831c5a50
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spelling	oai:doaj.org-article:34eb2c72ba2b44c2b7fd4909831c5a502021-12-02T18:15:35ZDirect detection of coupled proton and electron transfers in human manganese superoxide dismutase10.1038/s41467-021-22290-12041-1723https://doaj.org/article/34eb2c72ba2b44c2b7fd4909831c5a502021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22290-1https://doaj.org/toc/2041-1723Human manganese superoxide dismutase (MnSOD) is an oxidoreductase that uses concerted proton and electron transfers to reduce the levels of superoxide radicals in mitochondria, but mechanistic insights into this process are limited. Here, the authors report neutron crystal structures of Mn3+SOD and Mn2+SOD, revealing changes in the protonation states of key residues in the enzyme active site during the redox cycle.Jahaun AzadmaneshWilliam E. LutzLeighton CoatesKevin L. WeissGloria E. O. BorgstahlNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jahaun Azadmanesh William E. Lutz Leighton Coates Kevin L. Weiss Gloria E. O. Borgstahl Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
description	Human manganese superoxide dismutase (MnSOD) is an oxidoreductase that uses concerted proton and electron transfers to reduce the levels of superoxide radicals in mitochondria, but mechanistic insights into this process are limited. Here, the authors report neutron crystal structures of Mn3+SOD and Mn2+SOD, revealing changes in the protonation states of key residues in the enzyme active site during the redox cycle.
format	article
author	Jahaun Azadmanesh William E. Lutz Leighton Coates Kevin L. Weiss Gloria E. O. Borgstahl
author_facet	Jahaun Azadmanesh William E. Lutz Leighton Coates Kevin L. Weiss Gloria E. O. Borgstahl
author_sort	Jahaun Azadmanesh
title	Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
title_short	Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
title_full	Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
title_fullStr	Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
title_full_unstemmed	Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
title_sort	direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34eb2c72ba2b44c2b7fd4909831c5a50
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Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase

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