HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

<h4>Background</h4>HIV-1 Nef is a virulence factor that plays multiple roles during HIV replication. Recently, it has been described that Nef intersects the CD40 signalling in macrophages, leading to modification in the pattern of secreted factors that appear able to recruit, activate an...

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Autores principales: Giorgio Mangino, Zulema A Percario, Gianna Fiorucci, Gabriele Vaccari, Filippo Acconcia, Cristiano Chiarabelli, Stefano Leone, Alessia Noto, Florian A Horenkamp, Santiago Manrique, Giovanna Romeo, Fabio Polticelli, Matthias Geyer, Elisabetta Affabris
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/34fcc4205ca1453aabeae154c7d33f49
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