Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34

The E2 enzyme Cdc34 plays a critical role in cell cycle progression but the structural bases for its activities are unknown. Here, the authors present crystal structures of Cdc34 alone, in complex with E1, and in complex with Ub that provide insights into the mechanism of Cdc34 activity in the cell.

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Main Authors:	Katelyn M. Williams, Shuo Qie, James H. Atkison, Sabrina Salazar-Arango, J. Alan Diehl, Shaun K. Olsen
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/34fe16ea76e54aafba4e3a93fe290c25
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id	oai:doaj.org-article:34fe16ea76e54aafba4e3a93fe290c25
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spelling	oai:doaj.org-article:34fe16ea76e54aafba4e3a93fe290c252021-12-02T17:32:40ZStructural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc3410.1038/s41467-019-11061-82041-1723https://doaj.org/article/34fe16ea76e54aafba4e3a93fe290c252019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11061-8https://doaj.org/toc/2041-1723The E2 enzyme Cdc34 plays a critical role in cell cycle progression but the structural bases for its activities are unknown. Here, the authors present crystal structures of Cdc34 alone, in complex with E1, and in complex with Ub that provide insights into the mechanism of Cdc34 activity in the cell.Katelyn M. WilliamsShuo QieJames H. AtkisonSabrina Salazar-ArangoJ. Alan DiehlShaun K. OlsenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katelyn M. Williams Shuo Qie James H. Atkison Sabrina Salazar-Arango J. Alan Diehl Shaun K. Olsen Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
description	The E2 enzyme Cdc34 plays a critical role in cell cycle progression but the structural bases for its activities are unknown. Here, the authors present crystal structures of Cdc34 alone, in complex with E1, and in complex with Ub that provide insights into the mechanism of Cdc34 activity in the cell.
format	article
author	Katelyn M. Williams Shuo Qie James H. Atkison Sabrina Salazar-Arango J. Alan Diehl Shaun K. Olsen
author_facet	Katelyn M. Williams Shuo Qie James H. Atkison Sabrina Salazar-Arango J. Alan Diehl Shaun K. Olsen
author_sort	Katelyn M. Williams
title	Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
title_short	Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
title_full	Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
title_fullStr	Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
title_full_unstemmed	Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
title_sort	structural insights into e1 recognition and the ubiquitin-conjugating activity of the e2 enzyme cdc34
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/34fe16ea76e54aafba4e3a93fe290c25
work_keys_str_mv	AT katelynmwilliams structuralinsightsintoe1recognitionandtheubiquitinconjugatingactivityofthee2enzymecdc34 AT shuoqie structuralinsightsintoe1recognitionandtheubiquitinconjugatingactivityofthee2enzymecdc34 AT jameshatkison structuralinsightsintoe1recognitionandtheubiquitinconjugatingactivityofthee2enzymecdc34 AT sabrinasalazararango structuralinsightsintoe1recognitionandtheubiquitinconjugatingactivityofthee2enzymecdc34 AT jalandiehl structuralinsightsintoe1recognitionandtheubiquitinconjugatingactivityofthee2enzymecdc34 AT shaunkolsen structuralinsightsintoe1recognitionandtheubiquitinconjugatingactivityofthee2enzymecdc34
_version_	1718380240327147520

Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34

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