Targeted Knockout of the <named-content content-type="genus-species">Rickettsia rickettsii</named-content> OmpA Surface Antigen Does Not Diminish Virulence in a Mammalian Model System

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Targeted Knockout of the <named-content content-type="genus-species">Rickettsia rickettsii</named-content> OmpA Surface Antigen Does Not Diminish Virulence in a Mammalian Model System

ABSTRACT Strains of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever (RMSF), differ dramatically in virulence despite >99% genetic homology. Spotted fever group (SFG) rickettsiae produce two immunodominant outer membrane proteins, rickettsial OmpA (rOmpA) and rOmpB, whic...

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Detalles Bibliográficos
Autores principales:	Nicholas F. Noriea, Tina R. Clark, Ted Hackstadt
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/350a310c223c41e8963c69942a4305a3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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