Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration

Neuroscience: Vision is stressful for old flies Paradoxically, light is essential for vision, yet it also induces stress that damages the sensitive cells in the eye. Vikki Weake and her team at Purdue University examined how exposure to blue light causes damage to the retina in fruit flies. Blue lig...

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Autores principales:	Xinping Chen, Hana Hall, Jeffrey P. Simpson, Walter D. Leon-Salas, Donald F. Ready, Vikki M. Weake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/350f1843fb0d44c8be07118b75d08bfb
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spelling	oai:doaj.org-article:350f1843fb0d44c8be07118b75d08bfb2021-12-02T13:41:46ZCytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration10.1038/s41514-017-0019-62056-3973https://doaj.org/article/350f1843fb0d44c8be07118b75d08bfb2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0019-6https://doaj.org/toc/2056-3973Neuroscience: Vision is stressful for old flies Paradoxically, light is essential for vision, yet it also induces stress that damages the sensitive cells in the eye. Vikki Weake and her team at Purdue University examined how exposure to blue light causes damage to the retina in fruit flies. Blue light causes death of photoreceptors, the light-sensing neurons. Surprisingly, very young flies are resistant to blue light. Increasing levels of a single protein, Cytochrome-b5, mimicked youthful resilience in older flies. Cytochrome-b5 is central to an ancient cellular defense system that protects membranes from oxidative damage. With expansive sensory membranes containing specialized lipids, photoreceptors are especially sensitive to membrane lipid peroxidation, an emerging final common pathway for cell death in aging and disease. Research into preventing lipid peroxidation might help to develop therapies for age-related diseases such as age-related macular degeneration.Xinping ChenHana HallJeffrey P. SimpsonWalter D. Leon-SalasDonald F. ReadyVikki M. WeakeNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Xinping Chen Hana Hall Jeffrey P. Simpson Walter D. Leon-Salas Donald F. Ready Vikki M. Weake Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
description	Neuroscience: Vision is stressful for old flies Paradoxically, light is essential for vision, yet it also induces stress that damages the sensitive cells in the eye. Vikki Weake and her team at Purdue University examined how exposure to blue light causes damage to the retina in fruit flies. Blue light causes death of photoreceptors, the light-sensing neurons. Surprisingly, very young flies are resistant to blue light. Increasing levels of a single protein, Cytochrome-b5, mimicked youthful resilience in older flies. Cytochrome-b5 is central to an ancient cellular defense system that protects membranes from oxidative damage. With expansive sensory membranes containing specialized lipids, photoreceptors are especially sensitive to membrane lipid peroxidation, an emerging final common pathway for cell death in aging and disease. Research into preventing lipid peroxidation might help to develop therapies for age-related diseases such as age-related macular degeneration.
format	article
author	Xinping Chen Hana Hall Jeffrey P. Simpson Walter D. Leon-Salas Donald F. Ready Vikki M. Weake
author_facet	Xinping Chen Hana Hall Jeffrey P. Simpson Walter D. Leon-Salas Donald F. Ready Vikki M. Weake
author_sort	Xinping Chen
title	Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
title_short	Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
title_full	Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
title_fullStr	Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
title_full_unstemmed	Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
title_sort	cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/350f1843fb0d44c8be07118b75d08bfb
work_keys_str_mv	AT xinpingchen cytochromeb5protectsphotoreceptorsfromlightstressinducedlipidperoxidationandretinaldegeneration AT hanahall cytochromeb5protectsphotoreceptorsfromlightstressinducedlipidperoxidationandretinaldegeneration AT jeffreypsimpson cytochromeb5protectsphotoreceptorsfromlightstressinducedlipidperoxidationandretinaldegeneration AT walterdleonsalas cytochromeb5protectsphotoreceptorsfromlightstressinducedlipidperoxidationandretinaldegeneration AT donaldfready cytochromeb5protectsphotoreceptorsfromlightstressinducedlipidperoxidationandretinaldegeneration AT vikkimweake cytochromeb5protectsphotoreceptorsfromlightstressinducedlipidperoxidationandretinaldegeneration
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Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration

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