<italic toggle="yes">De Novo</italic> Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>
ABSTRACT The use of amphotericin B (AmB) in conjunction with 5-fluorocytosine (5-FC) is known to be the optimal therapy for treating cryptococcosis, but the mechanism by which 5-FC synergizes with AmB is unknown. In this study, we generated a Cryptococcus neoformansura1Δ mutant lacking dihydroorotat...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2016
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| Subjects: | |
| Online Access: | https://doaj.org/article/352b6dce94c0481fbdab1987d07eb3a2 |
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