<italic toggle="yes">De Novo</italic> Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>

<italic toggle="yes">De Novo</italic> Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>

ABSTRACT The use of amphotericin B (AmB) in conjunction with 5-fluorocytosine (5-FC) is known to be the optimal therapy for treating cryptococcosis, but the mechanism by which 5-FC synergizes with AmB is unknown. In this study, we generated a Cryptococcus neoformansura1Δ mutant lacking dihydroorotat...

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Bibliographic Details
Main Authors: Dithi Banerjee, Timothy C. Umland, John C. Panepinto
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
amphotericin B
cell wall integrity
pyrimidine biosynthesis
Microbiology
QR1-502
Online Access:https://doaj.org/article/352b6dce94c0481fbdab1987d07eb3a2
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