Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.

During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth p...

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Autores principales:	Johan Kerkhofs, Scott J Roberts, Frank P Luyten, Hans Van Oosterwyck, Liesbet Geris
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3587aac68a6c42ef9fc3ed50a70e8600
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id	oai:doaj.org-article:3587aac68a6c42ef9fc3ed50a70e8600
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spelling	oai:doaj.org-article:3587aac68a6c42ef9fc3ed50a70e86002021-11-18T07:20:14ZRelating the chondrocyte gene network to growth plate morphology: from genes to phenotype.1932-620310.1371/journal.pone.0034729https://doaj.org/article/3587aac68a6c42ef9fc3ed50a70e86002012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558096/?tool=EBIhttps://doaj.org/toc/1932-6203During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.Johan KerkhofsScott J RobertsFrank P LuytenHans Van OosterwyckLiesbet GerisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34729 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johan Kerkhofs Scott J Roberts Frank P Luyten Hans Van Oosterwyck Liesbet Geris Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
description	During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.
format	article
author	Johan Kerkhofs Scott J Roberts Frank P Luyten Hans Van Oosterwyck Liesbet Geris
author_facet	Johan Kerkhofs Scott J Roberts Frank P Luyten Hans Van Oosterwyck Liesbet Geris
author_sort	Johan Kerkhofs
title	Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_short	Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_full	Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_fullStr	Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_full_unstemmed	Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_sort	relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3587aac68a6c42ef9fc3ed50a70e8600
work_keys_str_mv	AT johankerkhofs relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype AT scottjroberts relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype AT frankpluyten relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype AT hansvanoosterwyck relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype AT liesbetgeris relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype
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Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.

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