Antibodies against alpha-synuclein reduce oligomerization in living cells.

Recent research implicates soluble aggregated forms of α-synuclein as neurotoxic species with a central role in the pathogenesis of Parkinson's disease and related disorders. The pathway by which α-synuclein aggregates is believed to follow a step-wise pattern, in which dimers and smaller oligo...

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Autores principales: Thomas Näsström, Susana Gonçalves, Charlotte Sahlin, Eva Nordström, Valentina Screpanti Sundquist, Lars Lannfelt, Joakim Bergström, Tiago F Outeiro, Martin Ingelsson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/36540fddbde747e09f645e1c2d74f401
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