Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction.

Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members encoded by multigene families in rodents and primates. In human pregnancy, PSGs are secreted by the syncytiotrophoblast, a fetal tissue, and reach a concentration of up to 400 ug/ml in the maternal bloodstream at term. Hu...

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Autores principales: Daniel K Shanley, Patrick A Kiely, Kalyan Golla, Seamus Allen, Kenneth Martin, Ronan T O'Riordan, Melanie Ball, John D Aplin, Bernhard B Singer, Noel Caplice, Niamh Moran, Tom Moore
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/36cc399900a842d09f227e777a1b78db
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