Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild conditions.

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Autores principales: Pei Liu, Changpeng Chen, Xuefeng Cong, Jinghua Tang, Xiaoming Zeng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/36d4db8f29df4dba8e839983948971d6
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