Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Abstract Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential pathological role, and detoxificatio...

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Main Authors: Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde
Format: article
Language:EN
Published: BMC 2021
Subjects:
Acrolein
Carnosine
Multiple sclerosis
Neuroinflammation
Oxidative stress
Reactive carbonyl
Neurology. Diseases of the nervous system
RC346-429
Online Access:https://doaj.org/article/3715f5de65d64b1e9a2469cd2e5cb244
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https://doaj.org/article/3715f5de65d64b1e9a2469cd2e5cb244

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