LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation

miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors report the host gene of miR-205, MIR205HG as a nuclear lincRNA that maintains the basal identity of prostate cell and prevents luminal cell differentiation via the repression of interferon responsive g...

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Autores principales:	Valentina Profumo, Barbara Forte, Stefano Percio, Federica Rotundo, Valentina Doldi, Elena Ferrari, Nicola Fenderico, Matteo Dugo, Dario Romagnoli, Matteo Benelli, Riccardo Valdagni, Diletta Dolfini, Nadia Zaffaroni, Paolo Gandellini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3732cd911d6749edbdf73c6627e1003f
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spelling	oai:doaj.org-article:3732cd911d6749edbdf73c6627e1003f2021-12-02T14:39:17ZLEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation10.1038/s41467-018-08153-22041-1723https://doaj.org/article/3732cd911d6749edbdf73c6627e1003f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08153-2https://doaj.org/toc/2041-1723miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors report the host gene of miR-205, MIR205HG as a nuclear lincRNA that maintains the basal identity of prostate cell and prevents luminal cell differentiation via the repression of interferon responsive genes.Valentina ProfumoBarbara ForteStefano PercioFederica RotundoValentina DoldiElena FerrariNicola FendericoMatteo DugoDario RomagnoliMatteo BenelliRiccardo ValdagniDiletta DolfiniNadia ZaffaroniPaolo GandelliniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Profumo Barbara Forte Stefano Percio Federica Rotundo Valentina Doldi Elena Ferrari Nicola Fenderico Matteo Dugo Dario Romagnoli Matteo Benelli Riccardo Valdagni Diletta Dolfini Nadia Zaffaroni Paolo Gandellini LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
description	miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors report the host gene of miR-205, MIR205HG as a nuclear lincRNA that maintains the basal identity of prostate cell and prevents luminal cell differentiation via the repression of interferon responsive genes.
format	article
author	Valentina Profumo Barbara Forte Stefano Percio Federica Rotundo Valentina Doldi Elena Ferrari Nicola Fenderico Matteo Dugo Dario Romagnoli Matteo Benelli Riccardo Valdagni Diletta Dolfini Nadia Zaffaroni Paolo Gandellini
author_facet	Valentina Profumo Barbara Forte Stefano Percio Federica Rotundo Valentina Doldi Elena Ferrari Nicola Fenderico Matteo Dugo Dario Romagnoli Matteo Benelli Riccardo Valdagni Diletta Dolfini Nadia Zaffaroni Paolo Gandellini
author_sort	Valentina Profumo
title	LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
title_short	LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
title_full	LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
title_fullStr	LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
title_full_unstemmed	LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
title_sort	leader role of mir-205 host gene as long noncoding rna in prostate basal cell differentiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3732cd911d6749edbdf73c6627e1003f
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LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation

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