Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.

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Autores principales:	Kazuki Kato, Yuhkoh Satouh, Hiroshi Nishimasu, Arisa Kurabayashi, Junko Morita, Yoshitaka Fujihara, Asami Oji, Ryuichiro Ishitani, Masahito Ikawa, Osamu Nureki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3749d191acf74d07b435e8cb1bfa0c4f
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spelling	oai:doaj.org-article:3749d191acf74d07b435e8cb1bfa0c4f2021-12-02T14:38:56ZStructural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization10.1038/ncomms121982041-1723https://doaj.org/article/3749d191acf74d07b435e8cb1bfa0c4f2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12198https://doaj.org/toc/2041-1723Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.Kazuki KatoYuhkoh SatouhHiroshi NishimasuArisa KurabayashiJunko MoritaYoshitaka FujiharaAsami OjiRyuichiro IshitaniMasahito IkawaOsamu NurekiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuki Kato Yuhkoh Satouh Hiroshi Nishimasu Arisa Kurabayashi Junko Morita Yoshitaka Fujihara Asami Oji Ryuichiro Ishitani Masahito Ikawa Osamu Nureki Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
description	Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.
format	article
author	Kazuki Kato Yuhkoh Satouh Hiroshi Nishimasu Arisa Kurabayashi Junko Morita Yoshitaka Fujihara Asami Oji Ryuichiro Ishitani Masahito Ikawa Osamu Nureki
author_facet	Kazuki Kato Yuhkoh Satouh Hiroshi Nishimasu Arisa Kurabayashi Junko Morita Yoshitaka Fujihara Asami Oji Ryuichiro Ishitani Masahito Ikawa Osamu Nureki
author_sort	Kazuki Kato
title	Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_short	Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_full	Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_fullStr	Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_full_unstemmed	Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
title_sort	structural and functional insights into izumo1 recognition by juno in mammalian fertilization
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3749d191acf74d07b435e8cb1bfa0c4f
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_version_	1718390764997705728

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

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