Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.

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Detalles Bibliográficos
Autores principales: Kazuki Kato, Yuhkoh Satouh, Hiroshi Nishimasu, Arisa Kurabayashi, Junko Morita, Yoshitaka Fujihara, Asami Oji, Ryuichiro Ishitani, Masahito Ikawa, Osamu Nureki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3749d191acf74d07b435e8cb1bfa0c4f
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