Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

During development, synapses are selectively strengthened or eliminated by activity-dependent competition. Here, the authors show that BDNF-TrkB retrograde signaling is a “punishment” signal that leads to elimination of climbing fiber-onto-Purkinje cell synapses in the developing cerebellum.

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Detalles Bibliográficos
Autores principales: Myeongjeong Choo, Taisuke Miyazaki, Maya Yamazaki, Meiko Kawamura, Takanobu Nakazawa, Jianling Zhang, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b578
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https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b578

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