Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

During development, synapses are selectively strengthened or eliminated by activity-dependent competition. Here, the authors show that BDNF-TrkB retrograde signaling is a “punishment” signal that leads to elimination of climbing fiber-onto-Purkinje cell synapses in the developing cerebellum.

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Autores principales:	Myeongjeong Choo, Taisuke Miyazaki, Maya Yamazaki, Meiko Kawamura, Takanobu Nakazawa, Jianling Zhang, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b578
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spelling	oai:doaj.org-article:3755b4a902f849c5a28ceb7f7043b5782021-12-02T14:16:31ZRetrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum10.1038/s41467-017-00260-w2041-1723https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b5782017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00260-whttps://doaj.org/toc/2041-1723During development, synapses are selectively strengthened or eliminated by activity-dependent competition. Here, the authors show that BDNF-TrkB retrograde signaling is a “punishment” signal that leads to elimination of climbing fiber-onto-Purkinje cell synapses in the developing cerebellum.Myeongjeong ChooTaisuke MiyazakiMaya YamazakiMeiko KawamuraTakanobu NakazawaJianling ZhangAsami TanimuraNaofumi UesakaMasahiko WatanabeKenji SakimuraMasanobu KanoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myeongjeong Choo Taisuke Miyazaki Maya Yamazaki Meiko Kawamura Takanobu Nakazawa Jianling Zhang Asami Tanimura Naofumi Uesaka Masahiko Watanabe Kenji Sakimura Masanobu Kano Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
description	During development, synapses are selectively strengthened or eliminated by activity-dependent competition. Here, the authors show that BDNF-TrkB retrograde signaling is a “punishment” signal that leads to elimination of climbing fiber-onto-Purkinje cell synapses in the developing cerebellum.
format	article
author	Myeongjeong Choo Taisuke Miyazaki Maya Yamazaki Meiko Kawamura Takanobu Nakazawa Jianling Zhang Asami Tanimura Naofumi Uesaka Masahiko Watanabe Kenji Sakimura Masanobu Kano
author_facet	Myeongjeong Choo Taisuke Miyazaki Maya Yamazaki Meiko Kawamura Takanobu Nakazawa Jianling Zhang Asami Tanimura Naofumi Uesaka Masahiko Watanabe Kenji Sakimura Masanobu Kano
author_sort	Myeongjeong Choo
title	Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
title_short	Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
title_full	Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
title_fullStr	Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
title_full_unstemmed	Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
title_sort	retrograde bdnf to trkb signaling promotes synapse elimination in the developing cerebellum
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b578
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Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

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