Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

During development, synapses are selectively strengthened or eliminated by activity-dependent competition. Here, the authors show that BDNF-TrkB retrograde signaling is a “punishment” signal that leads to elimination of climbing fiber-onto-Purkinje cell synapses in the developing cerebellum.

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Bibliographic Details
Main Authors: Myeongjeong Choo, Taisuke Miyazaki, Maya Yamazaki, Meiko Kawamura, Takanobu Nakazawa, Jianling Zhang, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b578
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https://doaj.org/article/3755b4a902f849c5a28ceb7f7043b578

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