Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in <italic toggle="yes">Pseudomonas aeruginosa</italic>

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in <italic toggle="yes">Pseudomonas aeruginosa</italic>

ABSTRACT While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome seq...

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Autores principales: Peter Jorth, Kathryn McLean, Anina Ratjen, Patrick R. Secor, Gilbert E. Bautista, Sumedha Ravishankar, Amir Rezayat, Jayanthi Garudathri, Joe J. Harrison, Rachel A. Harwood, Kelsi Penewit, Adam Waalkes, Pradeep K. Singh, Stephen J. Salipante
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Pseudomonas aeruginosa
antibiotic resistance
aztreonam
cystic fibrosis
fitness
selection
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/3789d0f4355743ab928140bb13ba807a
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https://doaj.org/article/3789d0f4355743ab928140bb13ba807a

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