Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

Abstract A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with th...

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Autores principales: Chaojie Zhong, Hongjie Xia, Awadalkareem Adam, Binbin Wang, Renee L. Hajnik, Yuejin Liang, Grace H. Rafael, Jing Zou, Xiaofang Wang, Jiaren Sun, Lynn Soong, Alan D. T. Barrett, Scott C. Weaver, Pei-Yong Shi, Tian Wang, Haitao Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/378daaf3c6264d6f95e72af6146211c7
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https://doaj.org/article/378daaf3c6264d6f95e72af6146211c7

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