Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

Abstract A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with th...

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Autores principales:	Chaojie Zhong, Hongjie Xia, Awadalkareem Adam, Binbin Wang, Renee L. Hajnik, Yuejin Liang, Grace H. Rafael, Jing Zou, Xiaofang Wang, Jiaren Sun, Lynn Soong, Alan D. T. Barrett, Scott C. Weaver, Pei-Yong Shi, Tian Wang, Haitao Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/378daaf3c6264d6f95e72af6146211c7
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spelling	oai:doaj.org-article:378daaf3c6264d6f95e72af6146211c72021-12-05T12:05:30ZMucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies10.1038/s41541-021-00405-52059-0105https://doaj.org/article/378daaf3c6264d6f95e72af6146211c72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00405-5https://doaj.org/toc/2059-0105Abstract A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine diminished viral loads and lung inflammation in mice after SARS-CoV-2 challenge, which correlated with the T-cell response induced by the vaccine in the lung, indicating that T-cell immunity is also likely critical for protection against SARS-CoV-2 infection in addition to neutralizing antibodies.Chaojie ZhongHongjie XiaAwadalkareem AdamBinbin WangRenee L. HajnikYuejin LiangGrace H. RafaelJing ZouXiaofang WangJiaren SunLynn SoongAlan D. T. BarrettScott C. WeaverPei-Yong ShiTian WangHaitao HuNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chaojie Zhong Hongjie Xia Awadalkareem Adam Binbin Wang Renee L. Hajnik Yuejin Liang Grace H. Rafael Jing Zou Xiaofang Wang Jiaren Sun Lynn Soong Alan D. T. Barrett Scott C. Weaver Pei-Yong Shi Tian Wang Haitao Hu Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
description	Abstract A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with the vaccine diminished viral loads and lung inflammation in mice after SARS-CoV-2 challenge, which correlated with the T-cell response induced by the vaccine in the lung, indicating that T-cell immunity is also likely critical for protection against SARS-CoV-2 infection in addition to neutralizing antibodies.
format	article
author	Chaojie Zhong Hongjie Xia Awadalkareem Adam Binbin Wang Renee L. Hajnik Yuejin Liang Grace H. Rafael Jing Zou Xiaofang Wang Jiaren Sun Lynn Soong Alan D. T. Barrett Scott C. Weaver Pei-Yong Shi Tian Wang Haitao Hu
author_facet	Chaojie Zhong Hongjie Xia Awadalkareem Adam Binbin Wang Renee L. Hajnik Yuejin Liang Grace H. Rafael Jing Zou Xiaofang Wang Jiaren Sun Lynn Soong Alan D. T. Barrett Scott C. Weaver Pei-Yong Shi Tian Wang Haitao Hu
author_sort	Chaojie Zhong
title	Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
title_short	Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
title_full	Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
title_fullStr	Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
title_full_unstemmed	Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
title_sort	mucosal vaccination induces protection against sars-cov-2 in the absence of detectable neutralizing antibodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/378daaf3c6264d6f95e72af6146211c7
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Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

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