RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.

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Auteurs principaux: Coralie Dorard, Charlène Estrada, Céline Barbotin, Magalie Larcher, Alexandra Garancher, Jessy Leloup, Friedrich Beermann, Manuela Baccarini, Celio Pouponnot, Lionel Larue, Alain Eychène, Sabine Druillennec
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/3790148bc8624695bd1b7e49449d5c3a
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https://doaj.org/article/3790148bc8624695bd1b7e49449d5c3a

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