RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.

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Autores principales:	Coralie Dorard, Charlène Estrada, Céline Barbotin, Magalie Larcher, Alexandra Garancher, Jessy Leloup, Friedrich Beermann, Manuela Baccarini, Celio Pouponnot, Lionel Larue, Alain Eychène, Sabine Druillennec
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3790148bc8624695bd1b7e49449d5c3a
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spelling	oai:doaj.org-article:3790148bc8624695bd1b7e49449d5c3a2021-12-02T17:06:02ZRAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma10.1038/ncomms152622041-1723https://doaj.org/article/3790148bc8624695bd1b7e49449d5c3a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15262https://doaj.org/toc/2041-1723The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.Coralie DorardCharlène EstradaCéline BarbotinMagalie LarcherAlexandra GarancherJessy LeloupFriedrich BeermannManuela BaccariniCelio PouponnotLionel LarueAlain EychèneSabine DruillennecNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Coralie Dorard Charlène Estrada Céline Barbotin Magalie Larcher Alexandra Garancher Jessy Leloup Friedrich Beermann Manuela Baccarini Celio Pouponnot Lionel Larue Alain Eychène Sabine Druillennec RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
description	The melanoma-driver mutations in NRAS and BRAF are mutually exclusive but the contribution of RAF signalling downstream of NRAS remains to be clarified. Here, using mouse models, the authors show specific roles of each member of the RAF family at different stages of melanomagenesis.
format	article
author	Coralie Dorard Charlène Estrada Céline Barbotin Magalie Larcher Alexandra Garancher Jessy Leloup Friedrich Beermann Manuela Baccarini Celio Pouponnot Lionel Larue Alain Eychène Sabine Druillennec
author_facet	Coralie Dorard Charlène Estrada Céline Barbotin Magalie Larcher Alexandra Garancher Jessy Leloup Friedrich Beermann Manuela Baccarini Celio Pouponnot Lionel Larue Alain Eychène Sabine Druillennec
author_sort	Coralie Dorard
title	RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
title_short	RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
title_full	RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
title_fullStr	RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
title_full_unstemmed	RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma
title_sort	raf proteins exert both specific and compensatory functions during tumour progression of nras-driven melanoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3790148bc8624695bd1b7e49449d5c3a
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RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

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