Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure
Summary: The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structure were examined in C57BL/6J mice randomized to co...
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Elsevier
2021
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oai:doaj.org-article:379150e318a640cc9c9a9ea0ac822fba2021-11-20T05:09:44ZKidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure2589-004210.1016/j.isci.2021.103308https://doaj.org/article/379150e318a640cc9c9a9ea0ac822fba2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012773https://doaj.org/toc/2589-0042Summary: The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structure were examined in C57BL/6J mice randomized to consume one of a spectrum of macronutrient combinations (protein [5%–60%], carbohydrate [20%–75%], and fat [20%–75%]) from weaning to late-middle age (15 months). Individual and interactive impacts of macronutrients on kidney health were modeled. Dietary protein had the greatest influence on kidney function, where chronic low protein intake decreased glomerular filtration rates and kidney mass, whereas it increased kidney immune infiltration and structural injury. Kidney outcomes did not align with cardiometabolic risk factors including glucose intolerance, overweight/obesity, dyslipidemia, and hypertension in mice with chronic low protein consumption. This study highlights that protein intake over a lifespan is an important determinant of kidney function independent of cardiometabolic changes.Amelia K. FotheringhamSamantha M. Solon-BietHelle Bielefeldt-OhmannDomenica A. McCarthyAisling C. McMahonKari RuohonenIsaac LiMitchell A. SullivanRani O. WhiddettDanielle J. BorgVictoria C. CoggerWilliam O. BallardNigel TurnerRichard G. MelvinDavid RaubenheimerDavid G. Le CouteurStephen J. SimpsonJosephine M. ForbesElsevierarticlePhysiologyAnimal physiologySystems biologyMetabolomicsScienceQENiScience, Vol 24, Iss 11, Pp 103308- (2021) |
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DOAJ |
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DOAJ |
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Physiology Animal physiology Systems biology Metabolomics Science Q |
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Physiology Animal physiology Systems biology Metabolomics Science Q Amelia K. Fotheringham Samantha M. Solon-Biet Helle Bielefeldt-Ohmann Domenica A. McCarthy Aisling C. McMahon Kari Ruohonen Isaac Li Mitchell A. Sullivan Rani O. Whiddett Danielle J. Borg Victoria C. Cogger William O. Ballard Nigel Turner Richard G. Melvin David Raubenheimer David G. Le Couteur Stephen J. Simpson Josephine M. Forbes Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| description |
Summary: The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structure were examined in C57BL/6J mice randomized to consume one of a spectrum of macronutrient combinations (protein [5%–60%], carbohydrate [20%–75%], and fat [20%–75%]) from weaning to late-middle age (15 months). Individual and interactive impacts of macronutrients on kidney health were modeled. Dietary protein had the greatest influence on kidney function, where chronic low protein intake decreased glomerular filtration rates and kidney mass, whereas it increased kidney immune infiltration and structural injury. Kidney outcomes did not align with cardiometabolic risk factors including glucose intolerance, overweight/obesity, dyslipidemia, and hypertension in mice with chronic low protein consumption. This study highlights that protein intake over a lifespan is an important determinant of kidney function independent of cardiometabolic changes. |
| format |
article |
| author |
Amelia K. Fotheringham Samantha M. Solon-Biet Helle Bielefeldt-Ohmann Domenica A. McCarthy Aisling C. McMahon Kari Ruohonen Isaac Li Mitchell A. Sullivan Rani O. Whiddett Danielle J. Borg Victoria C. Cogger William O. Ballard Nigel Turner Richard G. Melvin David Raubenheimer David G. Le Couteur Stephen J. Simpson Josephine M. Forbes |
| author_facet |
Amelia K. Fotheringham Samantha M. Solon-Biet Helle Bielefeldt-Ohmann Domenica A. McCarthy Aisling C. McMahon Kari Ruohonen Isaac Li Mitchell A. Sullivan Rani O. Whiddett Danielle J. Borg Victoria C. Cogger William O. Ballard Nigel Turner Richard G. Melvin David Raubenheimer David G. Le Couteur Stephen J. Simpson Josephine M. Forbes |
| author_sort |
Amelia K. Fotheringham |
| title |
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| title_short |
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| title_full |
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| title_fullStr |
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| title_full_unstemmed |
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| title_sort |
kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/379150e318a640cc9c9a9ea0ac822fba |
| work_keys_str_mv |
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