AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, Carine Delliaux, Chloé Apcher, Céline Schott, Rony Chidiac, Halil Bagci, Marie-Pier Thibault, Dominique Davidson, Mathieu Ferron, André Veillette, Roger J. Daly, Anne-Claude Gingras, Jean-Philippe Gratton, Jean-François Côté
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33

Documents similaires