AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.

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Bibliographic Details
Main Authors: Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, Carine Delliaux, Chloé Apcher, Céline Schott, Rony Chidiac, Halil Bagci, Marie-Pier Thibault, Dominique Davidson, Mathieu Ferron, André Veillette, Roger J. Daly, Anne-Claude Gingras, Jean-Philippe Gratton, Jean-François Côté
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33
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Internet

https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33

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