AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.

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Autores principales:	Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, Carine Delliaux, Chloé Apcher, Céline Schott, Rony Chidiac, Halil Bagci, Marie-Pier Thibault, Dominique Davidson, Mathieu Ferron, André Veillette, Roger J. Daly, Anne-Claude Gingras, Jean-Philippe Gratton, Jean-François Côté
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33
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spelling	oai:doaj.org-article:379ed28905e54ed3848a111bf0a70d332021-12-02T18:31:30ZAXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network10.1038/s41467-020-17415-x2041-1723https://doaj.org/article/379ed28905e54ed3848a111bf0a70d332020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17415-xhttps://doaj.org/toc/2041-1723AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.Afnan Abu-ThuraiaMarie-Anne GoyetteJonathan BoulaisCarine DelliauxChloé ApcherCéline SchottRony ChidiacHalil BagciMarie-Pier ThibaultDominique DavidsonMathieu FerronAndré VeilletteRoger J. DalyAnne-Claude GingrasJean-Philippe GrattonJean-François CôtéNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Afnan Abu-Thuraia Marie-Anne Goyette Jonathan Boulais Carine Delliaux Chloé Apcher Céline Schott Rony Chidiac Halil Bagci Marie-Pier Thibault Dominique Davidson Mathieu Ferron André Veillette Roger J. Daly Anne-Claude Gingras Jean-Philippe Gratton Jean-François Côté AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
description	AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.
format	article
author	Afnan Abu-Thuraia Marie-Anne Goyette Jonathan Boulais Carine Delliaux Chloé Apcher Céline Schott Rony Chidiac Halil Bagci Marie-Pier Thibault Dominique Davidson Mathieu Ferron André Veillette Roger J. Daly Anne-Claude Gingras Jean-Philippe Gratton Jean-François Côté
author_facet	Afnan Abu-Thuraia Marie-Anne Goyette Jonathan Boulais Carine Delliaux Chloé Apcher Céline Schott Rony Chidiac Halil Bagci Marie-Pier Thibault Dominique Davidson Mathieu Ferron André Veillette Roger J. Daly Anne-Claude Gingras Jean-Philippe Gratton Jean-François Côté
author_sort	Afnan Abu-Thuraia
title	AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
title_short	AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
title_full	AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
title_fullStr	AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
title_full_unstemmed	AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
title_sort	axl confers cell migration and invasion by hijacking a peak1-regulated focal adhesion protein network
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33
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AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

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