ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models.
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Nature Portfolio
2021
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oai:doaj.org-article:37a0f877c7f0425f889b230ea8fdf5222021-11-28T12:33:23ZACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury10.1038/s41467-021-27097-82041-1723https://doaj.org/article/37a0f877c7f0425f889b230ea8fdf5222021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27097-8https://doaj.org/toc/2041-1723Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models.Tomokazu YamaguchiMidori HoshizakiTakafumi MinatoSatoru NirasawaMasamitsu N. AsakaMayumi NiiyamaMasaki ImaiAkihiko UdaJasper Fuk-Woo ChanSaori TakahashiJianbo AnAkari SakuRyota NukiwaDaichi UtsumiMaki KisoAtsuhiro YasuharaVincent Kwok-Man PoonChris Chung-Sing ChanYuji FujinoSatoru MotoyamaSatoshi NagataJosef M. PenningerHaruhiko KamadaKwok-Yung YuenWataru KamitaniKen MaedaYoshihiro KawaokaYasuhiro YasutomiYumiko ImaiKeiji KubaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tomokazu Yamaguchi Midori Hoshizaki Takafumi Minato Satoru Nirasawa Masamitsu N. Asaka Mayumi Niiyama Masaki Imai Akihiko Uda Jasper Fuk-Woo Chan Saori Takahashi Jianbo An Akari Saku Ryota Nukiwa Daichi Utsumi Maki Kiso Atsuhiro Yasuhara Vincent Kwok-Man Poon Chris Chung-Sing Chan Yuji Fujino Satoru Motoyama Satoshi Nagata Josef M. Penninger Haruhiko Kamada Kwok-Yung Yuen Wataru Kamitani Ken Maeda Yoshihiro Kawaoka Yasuhiro Yasutomi Yumiko Imai Keiji Kuba ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury |
| description |
Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can inhibit SARS-CoV-2 infection acting as a decoy. Here the authors show that B38-CAP, an ACE2-like enzyme but not a decoy for the virus, is protective against SARS-CoV-2-induced lung injury in animal models. |
| format |
article |
| author |
Tomokazu Yamaguchi Midori Hoshizaki Takafumi Minato Satoru Nirasawa Masamitsu N. Asaka Mayumi Niiyama Masaki Imai Akihiko Uda Jasper Fuk-Woo Chan Saori Takahashi Jianbo An Akari Saku Ryota Nukiwa Daichi Utsumi Maki Kiso Atsuhiro Yasuhara Vincent Kwok-Man Poon Chris Chung-Sing Chan Yuji Fujino Satoru Motoyama Satoshi Nagata Josef M. Penninger Haruhiko Kamada Kwok-Yung Yuen Wataru Kamitani Ken Maeda Yoshihiro Kawaoka Yasuhiro Yasutomi Yumiko Imai Keiji Kuba |
| author_facet |
Tomokazu Yamaguchi Midori Hoshizaki Takafumi Minato Satoru Nirasawa Masamitsu N. Asaka Mayumi Niiyama Masaki Imai Akihiko Uda Jasper Fuk-Woo Chan Saori Takahashi Jianbo An Akari Saku Ryota Nukiwa Daichi Utsumi Maki Kiso Atsuhiro Yasuhara Vincent Kwok-Man Poon Chris Chung-Sing Chan Yuji Fujino Satoru Motoyama Satoshi Nagata Josef M. Penninger Haruhiko Kamada Kwok-Yung Yuen Wataru Kamitani Ken Maeda Yoshihiro Kawaoka Yasuhiro Yasutomi Yumiko Imai Keiji Kuba |
| author_sort |
Tomokazu Yamaguchi |
| title |
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury |
| title_short |
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury |
| title_full |
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury |
| title_fullStr |
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury |
| title_full_unstemmed |
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury |
| title_sort |
ace2-like carboxypeptidase b38-cap protects from sars-cov-2-induced lung injury |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/37a0f877c7f0425f889b230ea8fdf522 |
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