High-Throughput Screening Identifies Genes Required for <italic toggle="yes">Candida albicans</italic> Induction of Macrophage Pyroptosis

High-Throughput Screening Identifies Genes Required for <italic toggle="yes">Candida albicans</italic> Induction of Macrophage Pyroptosis

ABSTRACT The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans undergoes a morphogenetic switch coupled to cell wal...

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Main Authors: Teresa R. O’Meara, Kwamaa Duah, Cynthia X. Guo, Michelle E. Maxson, Ryan G. Gaudet, Kristy Koselny, Melanie Wellington, Michael E. Powers, Jessie MacAlpine, Matthew J. O’Meara, Amanda O. Veri, Sergio Grinstein, Suzanne M. Noble, Damian Krysan, Scott D. Gray-Owen, Leah E. Cowen
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Candida
cell wall remodelling
functional genomics
fungal morphogenesis
fungal pathogenesis
host-pathogen interaction
Microbiology
QR1-502
Online Access:https://doaj.org/article/37c1c8c11e4b4ed3843ff6f59b92ef9d
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https://doaj.org/article/37c1c8c11e4b4ed3843ff6f59b92ef9d

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