Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England

Abstract Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an emerging problem in many parts of the world. LA-MRSA has been isolated previously from animals and humans in the United Kingdom (UK), but the prevalence is unknown. The aim of this study was to determine the pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ewan M. Harrison, Francesc Coll, Michelle S. Toleman, Beth Blane, Nicholas M. Brown, M. Estee Török, Julian Parkhill, Sharon J. Peacock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/37db055b67504be0b6221797fe9659e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:37db055b67504be0b6221797fe9659e3
record_format	dspace
spelling	oai:doaj.org-article:37db055b67504be0b6221797fe9659e32021-12-02T11:40:42ZGenomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England10.1038/s41598-017-07662-22045-2322https://doaj.org/article/37db055b67504be0b6221797fe9659e32017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07662-2https://doaj.org/toc/2045-2322Abstract Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an emerging problem in many parts of the world. LA-MRSA has been isolated previously from animals and humans in the United Kingdom (UK), but the prevalence is unknown. The aim of this study was to determine the prevalence and to describe the molecular epidemiology of LA-MRSA isolated in the East of England (broadly Cambridge and the surrounding area). We accessed whole genome sequence data for 2,283 MRSA isolates from 1,465 people identified during a 12-month prospective study between 2012 and 2013 conducted in the East of England, United Kingdom. This laboratory serves four hospitals and 75 general practices. We screened the collection for multilocus sequence types (STs) and for host specific resistance and virulence factors previously associated with LA-MRSA. We identified 13 putative LA-MRSA isolates from 12 individuals, giving an estimated prevalence of 0.82% (95% CI 0.47% to 1.43%). Twelve isolates were mecC-MRSA (ten CC130, one ST425 and one ST1943) and single isolate was ST398. Our data demonstrate a low burden of LA-MRSA in the East of England, but the detection of mecC-MRSA and ST398 indicates the need for vigilance. Genomic surveillance provides a mechanism to detect and track the emergence and spread of MRSA clones of human importance.Ewan M. HarrisonFrancesc CollMichelle S. TolemanBeth BlaneNicholas M. BrownM. Estee TörökJulian ParkhillSharon J. PeacockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ewan M. Harrison Francesc Coll Michelle S. Toleman Beth Blane Nicholas M. Brown M. Estee Török Julian Parkhill Sharon J. Peacock Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England
description	Abstract Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an emerging problem in many parts of the world. LA-MRSA has been isolated previously from animals and humans in the United Kingdom (UK), but the prevalence is unknown. The aim of this study was to determine the prevalence and to describe the molecular epidemiology of LA-MRSA isolated in the East of England (broadly Cambridge and the surrounding area). We accessed whole genome sequence data for 2,283 MRSA isolates from 1,465 people identified during a 12-month prospective study between 2012 and 2013 conducted in the East of England, United Kingdom. This laboratory serves four hospitals and 75 general practices. We screened the collection for multilocus sequence types (STs) and for host specific resistance and virulence factors previously associated with LA-MRSA. We identified 13 putative LA-MRSA isolates from 12 individuals, giving an estimated prevalence of 0.82% (95% CI 0.47% to 1.43%). Twelve isolates were mecC-MRSA (ten CC130, one ST425 and one ST1943) and single isolate was ST398. Our data demonstrate a low burden of LA-MRSA in the East of England, but the detection of mecC-MRSA and ST398 indicates the need for vigilance. Genomic surveillance provides a mechanism to detect and track the emergence and spread of MRSA clones of human importance.
format	article
author	Ewan M. Harrison Francesc Coll Michelle S. Toleman Beth Blane Nicholas M. Brown M. Estee Török Julian Parkhill Sharon J. Peacock
author_facet	Ewan M. Harrison Francesc Coll Michelle S. Toleman Beth Blane Nicholas M. Brown M. Estee Török Julian Parkhill Sharon J. Peacock
author_sort	Ewan M. Harrison
title	Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England
title_short	Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England
title_full	Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England
title_fullStr	Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England
title_full_unstemmed	Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England
title_sort	genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant staphylococcus aureus in the east of england
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/37db055b67504be0b6221797fe9659e3
work_keys_str_mv	AT ewanmharrison genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT francesccoll genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT michellestoleman genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT bethblane genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT nicholasmbrown genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT mesteetorok genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT julianparkhill genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland AT sharonjpeacock genomicsurveillancerevealslowprevalenceoflivestockassociatedmethicillinresistantstaphylococcusaureusintheeastofengland
_version_	1718395573730541568

Genomic surveillance reveals low prevalence of livestock-associated methicillin-resistant Staphylococcus aureus in the East of England

Ejemplares similares