Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment

Abstract Mitochondrial diseases currently have no cure regardless of whether the cause is a nuclear or mitochondrial genome mutation. Mitochondrial dysfunction notably affects a wide range of disorders in aged individuals, including neurodegenerative diseases, cancers, and even senescence. Here, we...

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Bibliographic Details
Main Authors: Hideki Maeda, Daisuke Kami, Ryotaro Maeda, Akira Shikuma, Satoshi Gojo
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/382aa1c322d84db991fd3411ff052609
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