A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice

UVRAG is involved in autophagy, which loses its tumour suppressor functions when in its truncated form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein and show impaired autophagy, enhanced inflammation and β-catenin stabilisation, which promotes spontane...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Christine Quach, Ying Song, Hongrui Guo, Shun Li, Hadi Maazi, Marshall Fung, Nathaniel Sands, Douglas O’Connell, Sara Restrepo-Vassalli, Billy Chai, Dali Nemecio, Vasu Punj, Omid Akbari, Gregory E. Idos, Shannon M. Mumenthaler, Nancy Wu, Sue Ellen Martin, Ashley Hagiya, James Hicks, Hengmin Cui, Chengyu Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3853dd7ac3f64a118db62600822a7e0c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/3853dd7ac3f64a118db62600822a7e0c

Ejemplares similares