A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
UVRAG is involved in autophagy, which loses its tumour suppressor functions when in its truncated form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein and show impaired autophagy, enhanced inflammation and β-catenin stabilisation, which promotes spontane...
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Nature Portfolio
2019
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oai:doaj.org-article:3853dd7ac3f64a118db62600822a7e0c2021-12-02T13:27:23ZA truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice10.1038/s41467-019-13475-w2041-1723https://doaj.org/article/3853dd7ac3f64a118db62600822a7e0c2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13475-whttps://doaj.org/toc/2041-1723UVRAG is involved in autophagy, which loses its tumour suppressor functions when in its truncated form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein and show impaired autophagy, enhanced inflammation and β-catenin stabilisation, which promotes spontaneous tumorigenesis.Christine QuachYing SongHongrui GuoShun LiHadi MaaziMarshall FungNathaniel SandsDouglas O’ConnellSara Restrepo-VassalliBilly ChaiDali NemecioVasu PunjOmid AkbariGregory E. IdosShannon M. MumenthalerNancy WuSue Ellen MartinAshley HagiyaJames HicksHengmin CuiChengyu LiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Christine Quach Ying Song Hongrui Guo Shun Li Hadi Maazi Marshall Fung Nathaniel Sands Douglas O’Connell Sara Restrepo-Vassalli Billy Chai Dali Nemecio Vasu Punj Omid Akbari Gregory E. Idos Shannon M. Mumenthaler Nancy Wu Sue Ellen Martin Ashley Hagiya James Hicks Hengmin Cui Chengyu Liang A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice |
| description |
UVRAG is involved in autophagy, which loses its tumour suppressor functions when in its truncated form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein and show impaired autophagy, enhanced inflammation and β-catenin stabilisation, which promotes spontaneous tumorigenesis. |
| format |
article |
| author |
Christine Quach Ying Song Hongrui Guo Shun Li Hadi Maazi Marshall Fung Nathaniel Sands Douglas O’Connell Sara Restrepo-Vassalli Billy Chai Dali Nemecio Vasu Punj Omid Akbari Gregory E. Idos Shannon M. Mumenthaler Nancy Wu Sue Ellen Martin Ashley Hagiya James Hicks Hengmin Cui Chengyu Liang |
| author_facet |
Christine Quach Ying Song Hongrui Guo Shun Li Hadi Maazi Marshall Fung Nathaniel Sands Douglas O’Connell Sara Restrepo-Vassalli Billy Chai Dali Nemecio Vasu Punj Omid Akbari Gregory E. Idos Shannon M. Mumenthaler Nancy Wu Sue Ellen Martin Ashley Hagiya James Hicks Hengmin Cui Chengyu Liang |
| author_sort |
Christine Quach |
| title |
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice |
| title_short |
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice |
| title_full |
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice |
| title_fullStr |
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice |
| title_full_unstemmed |
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice |
| title_sort |
truncating mutation in the autophagy gene uvrag drives inflammation and tumorigenesis in mice |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/3853dd7ac3f64a118db62600822a7e0c |
| work_keys_str_mv |
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| _version_ |
1718392968084193280 |