Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenici...

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Autores principales:	Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J. van Breemen, Juan Miguel Camacho-Sánchez, Judith A. Burger, Max Medina-Ramírez, Nuria González, Jose Alcami, Celia LaBranche, Gabriella Scarlatti, Marit J. van Gils, Max Crispin, David C. Montefiori, Andrew B. Ward, Gerrit Koopman, John P. Moore, Robin J. Shattock, Willy M. Bogers, Ian A. Wilson, Rogier W. Sanders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/385d5edce0af48848af24fbfd3bba2e8
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spelling	oai:doaj.org-article:385d5edce0af48848af24fbfd3bba2e82021-12-02T16:57:43ZStructure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence10.1038/s41467-019-10262-52041-1723https://doaj.org/article/385d5edce0af48848af24fbfd3bba2e82019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10262-5https://doaj.org/toc/2041-1723Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.Kwinten SliepenByung Woo HanIlja BontjerPetra MooijFernando GarcesAnna-Janina BehrensKimmo RantalainenSonu KumarAnita SarkarPhilip J. M. BrouwerYuanzi HuaMonica TolazziEdith SchermerJonathan L. TorresGabriel OzorowskiPatricia van der WoudeAlba Torrents de la PeñaMariëlle J. van BreemenJuan Miguel Camacho-SánchezJudith A. BurgerMax Medina-RamírezNuria GonzálezJose AlcamiCelia LaBrancheGabriella ScarlattiMarit J. van GilsMax CrispinDavid C. MontefioriAndrew B. WardGerrit KoopmanJohn P. MooreRobin J. ShattockWilly M. BogersIan A. WilsonRogier W. SandersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kwinten Sliepen Byung Woo Han Ilja Bontjer Petra Mooij Fernando Garces Anna-Janina Behrens Kimmo Rantalainen Sonu Kumar Anita Sarkar Philip J. M. Brouwer Yuanzi Hua Monica Tolazzi Edith Schermer Jonathan L. Torres Gabriel Ozorowski Patricia van der Woude Alba Torrents de la Peña Mariëlle J. van Breemen Juan Miguel Camacho-Sánchez Judith A. Burger Max Medina-Ramírez Nuria González Jose Alcami Celia LaBranche Gabriella Scarlatti Marit J. van Gils Max Crispin David C. Montefiori Andrew B. Ward Gerrit Koopman John P. Moore Robin J. Shattock Willy M. Bogers Ian A. Wilson Rogier W. Sanders Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
description	Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.
format	article
author	Kwinten Sliepen Byung Woo Han Ilja Bontjer Petra Mooij Fernando Garces Anna-Janina Behrens Kimmo Rantalainen Sonu Kumar Anita Sarkar Philip J. M. Brouwer Yuanzi Hua Monica Tolazzi Edith Schermer Jonathan L. Torres Gabriel Ozorowski Patricia van der Woude Alba Torrents de la Peña Mariëlle J. van Breemen Juan Miguel Camacho-Sánchez Judith A. Burger Max Medina-Ramírez Nuria González Jose Alcami Celia LaBranche Gabriella Scarlatti Marit J. van Gils Max Crispin David C. Montefiori Andrew B. Ward Gerrit Koopman John P. Moore Robin J. Shattock Willy M. Bogers Ian A. Wilson Rogier W. Sanders
author_facet	Kwinten Sliepen Byung Woo Han Ilja Bontjer Petra Mooij Fernando Garces Anna-Janina Behrens Kimmo Rantalainen Sonu Kumar Anita Sarkar Philip J. M. Brouwer Yuanzi Hua Monica Tolazzi Edith Schermer Jonathan L. Torres Gabriel Ozorowski Patricia van der Woude Alba Torrents de la Peña Mariëlle J. van Breemen Juan Miguel Camacho-Sánchez Judith A. Burger Max Medina-Ramírez Nuria González Jose Alcami Celia LaBranche Gabriella Scarlatti Marit J. van Gils Max Crispin David C. Montefiori Andrew B. Ward Gerrit Koopman John P. Moore Robin J. Shattock Willy M. Bogers Ian A. Wilson Rogier W. Sanders
author_sort	Kwinten Sliepen
title	Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
title_short	Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
title_full	Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
title_fullStr	Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
title_full_unstemmed	Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
title_sort	structure and immunogenicity of a stabilized hiv-1 envelope trimer based on a group-m consensus sequence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/385d5edce0af48848af24fbfd3bba2e8
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Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

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