Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors

Abstract Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and has demonstrated clinical activity in gastric/gastro...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Charles Caldwell, James B. Rottman, Will Paces, Elizabeth Bueche, Sofia Reitsma, Joseph Gibb, Vitria Adisetiyo, Michael S. Haas, Heidi Heath, Walter Newman, Jason Baum, Roberto Gianani, Michael H. Kagey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/386bfb9934384f32ac9a8bd2228acb37
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!