NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

QR Code

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can be ameliorated with the new drug, NitroSynapsin.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.
par: Eun-Gyung Cho, et autres
Publié: (2011)

Predicted transmembrane proteins with homology to Mef(A) are not responsible for complementing mef(A) deletion in the mef(A)–msr(D) macrolide efflux system in Streptococcus pneumoniae
par: Valeria Fox, et autres
Publié: (2021)

PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
par: Lily Paemka, et autres
Publié: (2013)

Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
par: Daehun Park, et autres
Publié: (2021)

Bispyrenylalkane Chemosensor for the Naked-eye Detection of Nitro-explosives
par: I. S. Kovalev, et autres
Publié: (2021)

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
par: Mohd Waseem Akhtar, et autres
Publié: (2016)

Vertebrate paralogous MEF2 genes: origin, conservation, and evolution.
par: Wenwu Wu, et autres
Publié: (2011)

Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers
par: S. W. Tobin, et autres
Publié: (2017)

MEF2C shapes the microtranscriptome during differentiation of skeletal muscles
par: Agnieszka Piasecka, et autres
Publié: (2021)

ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
par: ARAVENA C,MARÍA, et autres
Publié: (2010)

The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients
par: Başay Ö, et autres
Publié: (2016)

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
par: Zhaohui Gu, et autres
Publié: (2016)

Encapsulating nitroreductase into metal-organic framework: Boosting industrial performance for the reduction of nitro-aromatics
par: Baoxing Shen, et autres
Publié: (2021)

Simulación numérica de una mezcla asfáltica usando MEF y diseño de experimentos
par: NORAMBUENA-CONTRERAS,J, et autres
Publié: (2011)

Silencing of MEF2D by siRNA Loaded Selenium Nanoparticles for Ovarian Cancer Therapy
par: Wang C, et autres
Publié: (2020)

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
par: Wenyuan Wang, et autres
Publié: (2016)

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
par: Irene Moretti, et autres
Publié: (2016)

Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I.
par: Maila Giannandrea, et autres
Publié: (2013)

Deciphering the unusual fluorescence in weakly coupled bis-nitro-pyrrolo[3,2-b]pyrroles
par: Yevgen M. Poronik, et autres
Publié: (2020)

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway
par: Abrar Ul Haq Khan, et autres
Publié: (2017)

ELECTROCHEMICAL, ESR, THEORETICAL STUDIES AND in vitro ANTI-T. cruzi ACTIVITY OF 2-ORGANOMETALLIC-5-NITRO-BENZIMIDAZOLES
par: Barriga-González,Germán, et autres
Publié: (2020)

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1
par: Adrian Richter, et autres
Publié: (2018)

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids
par: Nadine Hellmuth, et autres
Publié: (2021)

MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury.
par: Xin Xia, et autres
Publié: (2020)

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
par: Aleksandra Deczkowska, et autres
Publié: (2017)

Reactive oxygen species mediate Epstein-Barr virus reactivation by N-methyl-N'-nitro-N-nitrosoguanidine.
par: Sheng-Yen Huang, et autres
Publié: (2013)

Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis
par: Zhang Guorong, et autres
Publié: (2021)

Mef2d acts upstream of muscle identity genes and couples lateral myogenesis to dermomyotome formation in Xenopus laevis.
par: Bruno Della Gaspera, et autres
Publié: (2012)

Biodegradation of P-nitro phenol using a novel bacterium Achromobacter denitrifacians isolated from industrial effluent water
par: Sreeja Mole S. S, et autres
Publié: (2021)

Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites
par: Hao Tang, et autres
Publié: (2017)

Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery
par: Danielle Weber-Adrian, et autres
Publié: (2021)

Computational evidence for nitro derivatives of quinoline and quinoline N-oxide as low-cost alternative for the treatment of SARS-CoV-2 infection
par: Letícia C. Assis, et autres
Publié: (2021)

Concentration, source identification, and exposure risk assessment of PM2.5-bound parent PAHs and nitro-PAHs in atmosphere from typical Chinese cities
par: Di Liu, et autres
Publié: (2017)

Role of pKa in establishing the crystal structures of six hydrogen-bonded compounds of 4-methylquinoline with different isomers of chloro- and nitro-substituted benzoic acids
par: Hiroyuki Ishida
Publié: (2021)

Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy
par: João Paulo Silva Nunes, et autres
Publié: (2021)

Modelizado y optimización de problemas biomecánicos mediante la combinación del método de los elementos finitos (mef) y técnicas avanzadas de optimización
par: Somovilla Gómez, Fátima
Publié: (2020)

eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.
par: Orli Yogev, et autres
Publié: (2013)

Evolución clínica de pacientes chilenos con tirosinemia tipo I tratados con 2-(2-nitro-4-trifluorometilbenzoil)-1,3-ciclohexanediona (NTBC)
par: Raimann,Erna, et autres
Publié: (2012)

PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus
par: Matthew T. Dinday, et autres
Publié: (2017)

Taller de habilidades del facilitador /
par: Escorihuela, José Luis
Publié: (2006)