Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit

Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit

Abstract Intratumoral heterogeneity in lung cancer is essential for evasion of immune surveillance by tumor cells and establishment of immunosuppression. Gathering data reveal that circular RNAs (circRNAs), play a role in the pathogenesis and progression of lung cancer. Particularly Kras-driven circ...

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Main Authors: Theodora Katopodi, Savvas Petanidis, Kalliopi Domvri, Paul Zarogoulidis, Doxakis Anestakis, Charalampos Charalampidis, Drosos Tsavlis, Chong Bai, Haidong Huang, Lutz Freitag, Wolfgang Hohenforst-Schmidt, Dimitris Matthaios, Konstantinos Porpodis
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/388a6ebb7f354e219da11d242f0c7a1d
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https://doaj.org/article/388a6ebb7f354e219da11d242f0c7a1d

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