uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

VEGF-C drives lymphangiogenesis through binding to its receptors VEGFR-2 and VEGFR-3. Here, Durré et al. identify uPARAP/Endo180 as a critical regulator of VEGFR-2/VEGFR-3 heterodimerisation and downstream signaling in response to VEGF-C, and show that uPARAP deletion leads to the formation of hyper...

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Autores principales:	Tania Durré, Florent Morfoisse, Charlotte Erpicum, Marie Ebroin, Silvia Blacher, Melissa García-Caballero, Christophe Deroanne, Thomas Louis, Cédric Balsat, Maureen Van de Velde, Seppo Kaijalainen, Frédéric Kridelka, Lars Engelholm, Ingrid Struman, Kari Alitalo, Niels Behrendt, Jenny Paupert, Agnès Noel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/38a29c790f274d7296f82886c67f9d1c
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spelling	oai:doaj.org-article:38a29c790f274d7296f82886c67f9d1c2021-12-02T13:24:34ZuPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis10.1038/s41467-018-07514-12041-1723https://doaj.org/article/38a29c790f274d7296f82886c67f9d1c2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07514-1https://doaj.org/toc/2041-1723VEGF-C drives lymphangiogenesis through binding to its receptors VEGFR-2 and VEGFR-3. Here, Durré et al. identify uPARAP/Endo180 as a critical regulator of VEGFR-2/VEGFR-3 heterodimerisation and downstream signaling in response to VEGF-C, and show that uPARAP deletion leads to the formation of hyperbranched vasculatures in pathological conditions.Tania DurréFlorent MorfoisseCharlotte ErpicumMarie EbroinSilvia BlacherMelissa García-CaballeroChristophe DeroanneThomas LouisCédric BalsatMaureen Van de VeldeSeppo KaijalainenFrédéric KridelkaLars EngelholmIngrid StrumanKari AlitaloNiels BehrendtJenny PaupertAgnès NoelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tania Durré Florent Morfoisse Charlotte Erpicum Marie Ebroin Silvia Blacher Melissa García-Caballero Christophe Deroanne Thomas Louis Cédric Balsat Maureen Van de Velde Seppo Kaijalainen Frédéric Kridelka Lars Engelholm Ingrid Struman Kari Alitalo Niels Behrendt Jenny Paupert Agnès Noel uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
description	VEGF-C drives lymphangiogenesis through binding to its receptors VEGFR-2 and VEGFR-3. Here, Durré et al. identify uPARAP/Endo180 as a critical regulator of VEGFR-2/VEGFR-3 heterodimerisation and downstream signaling in response to VEGF-C, and show that uPARAP deletion leads to the formation of hyperbranched vasculatures in pathological conditions.
format	article
author	Tania Durré Florent Morfoisse Charlotte Erpicum Marie Ebroin Silvia Blacher Melissa García-Caballero Christophe Deroanne Thomas Louis Cédric Balsat Maureen Van de Velde Seppo Kaijalainen Frédéric Kridelka Lars Engelholm Ingrid Struman Kari Alitalo Niels Behrendt Jenny Paupert Agnès Noel
author_facet	Tania Durré Florent Morfoisse Charlotte Erpicum Marie Ebroin Silvia Blacher Melissa García-Caballero Christophe Deroanne Thomas Louis Cédric Balsat Maureen Van de Velde Seppo Kaijalainen Frédéric Kridelka Lars Engelholm Ingrid Struman Kari Alitalo Niels Behrendt Jenny Paupert Agnès Noel
author_sort	Tania Durré
title	uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
title_short	uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
title_full	uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
title_fullStr	uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
title_full_unstemmed	uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
title_sort	uparap/endo180 receptor is a gatekeeper of vegfr-2/vegfr-3 heterodimerisation during pathological lymphangiogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/38a29c790f274d7296f82886c67f9d1c
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uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

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