ω-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1/M2 Polarizations through Inhibiting NF-κB/MAPK p38 Signaling and Activating Neuron-BDNF-PI3K/AKT Pathways

ω-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1/M2 Polarizations through Inhibiting NF-κB/MAPK p38 Signaling and Activating Neuron-BDNF-PI3K/AKT Pathways

Microglia M1 phenotype causes HPA axis hyperactivity, neurotransmitter dysfunction, and production of proinflammatory mediators and oxidants, which may contribute to the etiology of depression and neurodegenerative diseases. Eicosapentaenoic acid (EPA) may counteract neuroinflammation by increasing...

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Bibliographic Details
Main Authors: Baiping Liu, Yongping Zhang, Zhiyou Yang, Meijun Liu, Cai Zhang, Yuntao Zhao, Cai Song
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
omega-3 docosapentaenoic acid
neuroinflammation
neuroprotection
M1/M2 polarizations
microglia-NF-κB/MAPK p38 pathway
BDNF-PI3K/AKT pathway
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/38a9000840794214a3aff767fbfdd306
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https://doaj.org/article/38a9000840794214a3aff767fbfdd306

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